Biochemical and Metabolical Pathways Associated with Microbiota-Derived Butyrate in Colorectal Cancer and Omega-3 Fatty Acids Implications: A Narrative Review

被引：23
作者：
Gheorghe, Adelina Silvana [1 ]
Negru, Serban Mircea [2 ]
Preda, Madalina [3 ]
Mihaila, Raluca Ioana [1 ]
Komporaly, Isabela Anda [1 ]
Dumitrescu, Elena Adriana [1 ]
Lungulescu, Cristian Virgil [4 ]
Kajanto, Lidia Anca [1 ]
Georgescu, Bogdan [1 ]
Radu, Emanuel Alin [1 ]
Stanculeanu, Dana Lucia [1 ]
机构：
[1] Carol Davila Univ Med & Pharm, Dept Oncol, Bucharest 020021, Romania
[2] Victor Babes Univ Med & Pharm, Dept Oncol, Timisoara 300041, Romania
[3] Carol Davila Univ Med & Pharm, Fac Midw & Nursing, Dept Microbiol Parasitol & Virol, Bucharest 020021, Romania
[4] Univ Med & Pharm Craiova, Dept Med Oncol, Craiova 200349, Romania
来源：
NUTRIENTS | 2022年 / 14卷 / 06期
关键词：
butyrate; colorectal cancer; gut microbiota; diet; omega-3; PUFAs; GUT MICROBIOTA; GLYCEMIC LOAD; CELL-DEATH; DIET; CYTOSKELETAL; INFLAMMATION;
D O I：
10.3390/nu14061152
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Knowledge regarding the influence of the microbial community in cancer promotion or protection has expanded even more through the study of bacterial metabolic products and how they can modulate cancer risk, which represents an extremely challenging approach for the relationship between intestinal microbiota and colorectal cancer (CRC). This review discusses research progress on the effect of bacterial dysbiosis from a metabolic point of view, particularly on the biochemical mechanisms of butyrate, one of the main short chain fatty acids (SCFAs) with anti-inflammatory and anti-tumor properties in CRC. Increased daily intake of omega-3 polyunsaturated fatty acids (PUFAs) significantly increases the density of bacteria that are known to produce butyrate. Omega-3 PUFAs have been proposed as a treatment to prevent gut microbiota dysregulation and lower the risk or progression of CRC.
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页数：11
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