Vulvar and vaginal neoplasia in women with inflammatory bowel disease

被引：2

作者：

Rouvroye, Maxine D. ^{[1
]}

Tack, Greetje J. ^{[2
]}

Mom, Constantijne H. ^{[3
]}

Lissenberg-Witte, Birgit I. ^{[5
]}

Pierik, Marieke J. ^{[6
]}

Neefjes-Borst, E. Andra ^{[4
]}

De Boer, Nanne K. H. ^{[1
]}

Lowenberg, M. ^{[7
]}

Bodelier, A. ^{[8
]}

Verbeek, W. H. ^{[9
]}

Schoon, E. ^{[10
]}

Witteman, E. M. ^{[11
]}

Herwaarden, M. A. ^{[12
]}

Van der Woude, C. J. ^{[13
]}

Lutgens, M. ^{[14
]}

Kouw, E. ^{[15
]}

Van der Veek, P. J. ^{[16
]}

Van der Hulst, R. W. ^{[17
]}

Sipkema, H. ^{[18
]}

Nissen, L. H. C. ^{[19
]}

Bus, P. J. ^{[20
]}

van der Meulen, A. E. ^{[21
]}

De Bruijne, F. H.

van der Waaij, L. A.

Noomen, C. G. ^{[22
]}

Jharap, B. ^{[23
]}

Schmittgens, S. ^{[24
]}

Jansen, J. M. ^{[25
]}

Hoentjen, F. ^{[26
]}

Lammertink, M. H. A. ^{[27
]}

Houben, G. M. P. ^{[28
]}

Minderhoud, I. M. ^{[29
]}

Dijkstra, G. ^{[30
]}

Oldenburg, B. ^{[31
]}

Sikkens, M. S. G. ^{[32
]}

Van Tuyl, S. A. ^{[33
]}

van Bodegraven, A. A. ^{[34
]}

机构：

[1] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Gastroenterol & Metab, Gastroenterol & Hepatol, Amsterdam, Netherlands

[2] Leeuwarden Med Ctr, Dept Gastroenterol & Hepatol, Leeuwarden, Netherlands

[3] Vrije Univ Amsterdam, Amsterdam UMC, Gynecol & Obstet, Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Amsterdam UMC, Pathol, Amsterdam, Netherlands

[5] Vrije Univ Amsterdam, Amsterdam UMC, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[6] Maastricht Univ, Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol, Maastricht, Netherlands

[7] Univ Amsterdam, Med Ctr, Locat AMC, Amsterdam, Netherlands

[8] Amphia Ziekenhuis, Breda, Netherlands

[9] Antoni van Leeuwenhoek Ziekenhuis, Amsterdam, Netherlands

[10] Catharina Hosp, Eindhoven, Netherlands

[11] Canisius Wilhelmina Ziekenhuis, Nijmegen, Netherlands

[12] Deventer Ziekenhuis, Deventer, Netherlands

[13] Erasmus MC, Rotterdam, Netherlands

[14] Elisabeth TweeSteden Ziekenhuis, Tilburg, Netherlands

[15] Gelre Ziekenhuizen Apeldoorn, Apeldoorn, Netherlands

[16] Med Ctr Haaglanden, The Hague, Netherlands

[17] Spaarne Gasthuis, Haarlem, Netherlands

[18] Isala, Zwolle, Netherlands

[19] Jeroen Bosch Ziekenhuis, sHertogenbosch, Netherlands

[20] Laurentius Ziekenhuis, Roermond, Netherlands

[21] Leiden Univ, Med Ctr, Leiden, Netherlands

[22] Med Ctr Alkmaar, Alkmaar, Netherlands

[23] Meander Med Ctr, Amersfoort, Netherlands

[24] Nij Smellinghe Ziekenhuis, Drachten, Netherlands

[25] Onze Lieve Vrouwen Gasthuis, Amsterdam, Netherlands

[26] Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands

[27] Rijnstate Ziekenhuis, Arnhem, Netherlands

[28] Slotervaart Hosp, Amsterdam, Netherlands

[29] Tergooiziekenhuizen, Hilversum, Netherlands

[30] Univ Med Ctr Groningen, Groningen, Netherlands

[31] Univ Med Ctr Utrecht, Utrecht, Netherlands

[32] Westfries Gasthuis, Hoorn, Netherlands

[33] Diakonessen Hosp, Utrecht, Netherlands

[34] Zuyderland Ziekenhuis, Heerlen, Netherlands

来源：

DIGESTIVE AND LIVER DISEASE | 2020年 / 52卷 / 02期

关键词：

Inflammatory bowel disease; Immunosuppressive therapy; Vulvar or vaginal malignancy; FEMALE GENITAL-TRACT; HUMAN-PAPILLOMAVIRUS; INCREASED RISK; CANCER; COHORT; EPIDEMIOLOGY; THIOPURINES; PREVALENCE; SURVIVAL; TRENDS;

D O I：

10.1016/j.dld.2019.10.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Immunosuppressive drugs are the cornerstone in the treatment of inflammatory bowel disease (IBD), however they are associated with an increased risk of extra-intestinal cancer. Whether the risk for female genital tract malignancies, including vulvar and vaginal cancer, is increased is less clear. Our aim was to investigate the risk of these malignancies in IBD-patients. Histopathological data of all IBD patients with a vulvar or vaginal (pre-)cancerous lesion were retrieved from the Dutch nationwide network and registry of histopathology and cytopathology from 1991 to 2015. Medical history was retrieved from patient records. Data from the Central Office for Statistics, the Dutch comprehensive cancer organization, and the IBDSL cohort were obtained to calculate the standardized, and age-adjusted incidence rates. Fifty-five patients met the inclusion criteria. A standardized incidence rate of 1.2(95% CI:0.8-1.7) for vulvar and vaginal carcinoma among adult female IBD was calculated, which did not significantly differ from the general population. The use of immunosuppressive therapy did not increase the occurrence of vulvovaginal malignancy, nor did it influence the recurrence rate. However, immunosuppressive drugs ever-users were on average 11 years younger at the time of their gynaecological diagnosis. Overall, our data do not support intensified screening for vulvar or vaginal malignancies in female IBD patients. (C) 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：149 / 155

页数：7

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