The function of actin in gene transcription

被引：0

作者：

Obrdlik, A. ^{[1
]}

Kukalev, A. ^{[1
]}

Percipalle, P. ^{[1
]}

机构：

[1] Karolinska Inst, Med Novel Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden

来源：

HISTOLOGY AND HISTOPATHOLOGY | 2007年 / 22卷 / 09期

关键词：

nuclear actin; nuclear myosin; ribonucleoproteins; RNA polymerase; transcription;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent developments in the field of gene transcription regulation have unfolded a key role for actin as an important co-factor for all three eukaryotic RNA polymerases. In this review article we discuss the latest findings on actin in transcription of protein-coding and ribosomal genes, in complex with specific hnRNP proteins and a form of myosin 1 beta which is entirely localized to the cell nucleus. Based on these recent studies, we propose a general model where actin may function in basal gene transcription as an allosteric regulator, to recruit transcriptional co-activators on active genes. A future challenge will be the identification of the polymerization state of actin in gene transcription and how it is mechanistically regulated.

引用

页码：1051 / 1055

页数：5

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