A novel metal-organic frameworks composite-based label-free point-of-care quartz crystal microbalance aptasensing platform for tetracycline detection

被引：20

作者：

Yang, Yukun ^{[1
]}

Yang, Lanqing ^{[1
]}

Ma, Yuanyuan ^{[1
]}

Wang, Xiaomin ^{[2
]}

Zhang, Jinhua ^{[1
]}

Bai, Baoqing ^{[1
]}

Yu, Ligang ^{[1
]}

Guo, Caixia ^{[1
]}

Zhang, Fuyuan ^{[3
]}

Qin, Shu ^{[4
]}

机构：

[1] Shanxi Univ, Sch Life Sci, Taiyuan 030006, Peoples R China

[2] Shanxi Univ Chinese Med, Inst Pharmaceut & Food Engn, Yuci 030619, Peoples R China

[3] Hebei Agr Univ, Coll Food Sci & Technol, Baoding 071001, Peoples R China

[4] Shanxi Agr Univ, Shanxi Ctr Testing Funct Agroprod, Taiyuan 030031, Peoples R China

来源：

FOOD CHEMISTRY | 2022年 / 392卷

基金：

中国国家自然科学基金;

关键词：

Quartz crystal microbalance; Metal-organic frameworks; Aptamer; Gold nanoparticles; Tetracycline; Food safety; MOLECULARLY IMPRINTED POLYMER; SENSOR; NANOPARTICLES;

D O I：

10.1016/j.foodchem.2022.133302

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel label-free point-of-care quartz crystal microbalance (QCM) aptasensing platform based on metal-organic frameworks (MOFs) and gold nanoparticles (AuNPs) was fabricated for tetracycline (TC) detection. MOFs (HKUST-1) and AuNPs were modified onto the sensing interface of QCM sensor to enhance the sensing perfor-mance of the QCM aptasensor. TC aptamer with sulfhydryl group was fixed through Au-S bond. The recognition performance of the aptasensor was predicted and verified by the computer simulation. At the optimal conditions, the frequency change of the sensor was adopted for quantitative detection of TC. The prepared QCM aptasensor exhibited a wide linear range from 1 x 10(-10) g mL(-1) to 1 x 10(-5) g mL(-1) with low limit of detection (0.8 x 10(-11) g mL(-1)). High sensitivity, good selectivity, acceptable recoveries (87.6-91.4%) in real samples were ob-tained. For the first time, MOFs were utilized in the construction of QCM aptasensing platform, providing a promising application way of MOFs in the QCM sensing.

引用

页数：8

共 21 条

[21] Measurement of aflatoxin M1 in powder and pasteurized milk samples by using a label-free electrochemical aptasensor based on platinum nanoparticles loaded on Fe-based metal-organic frameworks
Jahangiri-Dehaghani, Fahime
Zare, Hamid R.
Shekari, Zahra
FOOD CHEMISTRY, 2020, 310

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