Recent Advances in the Design of Targeted Iridium(III) Photosensitizers for Photodynamic Therapy

被引：164
作者：
Huang, Huaiyi [1 ]
Banerjee, Samya [1 ]
Sadler, Peter J. [1 ]
机构：
[1] Univ Warwick, Dept Chem, Gibbet Hill, Coventry CV4 7AL, W Midlands, England
来源：
CHEMBIOCHEM | 2018年 / 19卷 / 15期
基金：
英国工程与自然科学研究理事会;
关键词：
cell imaging; cell organelles; iridium; photodynamic therapy; photosensitizers; FLUORESCENT-PROBE LOCALIZATION; POLYPYRIDINE COMPLEXES; CARBENE COMPLEXES; SINGLET OXYGEN; LIVING CELLS; CANCER-CELLS; MITOCHONDRIA; ANTICANCER; PHOTOCHEMISTRY; MECHANISMS;
D O I：
10.1002/cbic.201800182
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Photodynamic therapy (PDT) is a noninvasive treatment for certain types of cancer, bacterial, fungal and viral infections, and skin diseases. In recent years, adaptation of this treatment so as to achieve more specific targeted cancer therapy in particular has attracted significant attention. We focus herein on the design of novel iridium-based photosensitizers (PSs) with tunable photophysical and photobiological properties as efficient PDT agents. We highlight the ability of some Ir-III photosensitizers to target specific cellular components, including their activation by one- and two-photon irradiation.
引用
收藏
页码：1574 / 1589
页数：16
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