A novel synthesis of substituted 4H-pyrazolo[3,4-d]pyrimidin-4-ones

被引：6

作者：

Adams, Nicholas D. ^{[1
]}

Schmidt, Stanley J. ^{[1
]}

Knight, Steven D. ^{[1
]}

Dhanak, Dashyant ^{[1
]}

机构：

[1] GlaxoSmithKline, Dept Med Chem, Micobial Musculoskeletal & Proliferat Dis Ctr Exc, Collegeville, PA 19426 USA

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 23期

关键词：

D O I：

10.1016/j.tetlet.2007.04.043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel synthesis of 4H-pyrazolo-[3,4-d]pyrimidin-4-ones is described. This approach utilizes an in situ generated imino-chloride as a key precursor for amidine formation, with subsequent base-catalyzed ring closure. This method represents a mild and efficient entry into this ring system which is amenable to diversification of the core template. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3983 / 3986

页数：4

共 9 条

[1] Novel pyrazolo[3,4-d]pyrimidine-based inhibitors of Staphlococcus aureus DNA polymerase III:: Design, synthesis, and biological evaluation
Ali, A
Taylor, GE
Ellsworth, K
Harris, G
Painter, R
Silver, LL
Young, K
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (10) : 1824 - 1830
[2] (R)- and (S)-3-hydroxy-4,4-dimethyl-1-phenyl-2-pyrrolidinone as chiral auxiliaries in the enantioselective preparation of α-amino acids
Camps, P
Pérez, F
Soldevilla, N
Borrego, MA
[J]. TETRAHEDRON-ASYMMETRY, 1999, 10 (03) : 493 - 509
[3] Synthesis of derivatives of thiophene using methyl 2-isothiocyanatobenzoate
Deck, LM
Turner, SD
Deck, JA
Papadopoulos, EP
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2001, 38 (02) : 343 - 347
[4] FRALEY ME, 2003, Patent No. 03049572
[5] Green T.W., 1999, PROTECTIVE GROUPS OR, V3rd
[6] SYNTHESIS OF N-CARBOXY-ALPHA-AMINO ACID ANHYDRIDES
KONOPINSKA, D
SIEMION, IZ
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1967, 6 (03) : 248 - +
[7] PECH R, 1989, PHARMAZIE, V44, P790
[8] SYNTHESIS OF PYRAZOLO[3,4-D]PYRIMIDINE ANALOGS OF THE POTENT ANTITUMOR AGENT N-(4-[2-(2-AMINO-4(3H)-OXO-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]BENZOYL)-L-GLUTAMIC ACID (LY231514)
TAYLOR, EC
PATEL, HH
[J]. TETRAHEDRON, 1992, 48 (37) : 8089 - 8100
[9] WAMHOFF H, 1993, SYNTHESIS-STUTTGART, P107

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