Beetleane A and Epicoane A: Two Carbon Skeletons Produced by Epicoccum nigrum

被引：9

作者：

Cao, Peng-Ran ^{[1
,2
]}

Zheng, Yi-Lei ^{[1
,2
]}

Zhao, Yong-Qin ^{[1
,2
]}

Wang, Xiao-Bing ^{[1
,2
]}

Zhang, Hao ^{[1
,2
]}

Zhang, Mei-Hui ^{[1
,2
]}

Yang, Ting ^{[1
,2
]}

Gu, Yu-Cheng ^{[3
]}

Yang, Ming-Hua ^{[1
,2
]}

Kong, Ling-Yi ^{[1
,2
]}

机构：

[1] China Pharmaceut Univ, Jiangsu Key Lab Bioact Nat Prod Res, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China

[3] Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 09期

基金：

中国国家自然科学基金;

关键词：

BROWN-ROT;

D O I：

10.1021/acs.orglett.1c00731

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel natural products, beetleane A (1) and epicoane A (2), were obtained from the metabolites of an endophytic Epicoccum nigrum. Compound 1 has a unique beetlelike structure that is constructed by the fusion and further fold of an unusual [5.5.5.6]trioxafenestrane with a cycloheptane ring. Compound 2 possesses a compact cagelike structure with a unique 6/5/5/5/6/6/5 heptacyclic ring system. Both 1 and 2 showed strong antiliver fibrosis activity in vitro.

引用

页码：3274 / 3277

页数：4

共 19 条

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