A 10-Year Prospective Study of Bone Mineral Density and Bone Turnover in Males and Females With Type 1 Diabetes

被引：19

作者：

Hamilton, Emma J. ^{[1
,2
,3
]}

Drinkwater, Jocelyn J. ^{[1
]}

Chubb, S. A. Paul ^{[1
,4
]}

Rakic, Valentina ^{[1
]}

Kamber, Niklaus ^{[5
]}

Zhu, Kun ^{[6
,7
]}

Prince, Richard L. ^{[6
,7
]}

Davis, Wendy A. ^{[1
]}

Davis, Timothy M. E. ^{[1
]}

机构：

[1] Univ Western Australia, Fremantle Hosp, Sch Med, POB 480, Fremantle, WA 6959, Australia

[2] Fiona Stanley Hosp, Dept Endocrinol & Diabet, Murdoch, WA 6150, Australia

[3] Univ Western Australia, Fiona Stanley Hosp, Sch Med, Murdoch, WA 6150, Australia

[4] Fiona Stanley Hosp, PathWest, Dept Biochem, Murdoch, WA 6150, Australia

[5] Kantonsspital Graubunden, Dept Endocrinol, CH-7000 Chur, Switzerland

[6] Sir Charles Gairdner Hosp, Dept Endocrinol & Diabet, Nedlands, WA 6009, Australia

[7] Univ Western Australia, Sch Med, Sir Charles Gairdner Hosp, Nedlands, WA 6009, Australia

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2018年 / 103卷 / 09期

基金：

英国医学研究理事会;

关键词：

FRACTURE RISK; CORTICAL BONE; HIP FRACTURE; MELLITUS; OSTEOPOROSIS; FRAGILITY; MARKERS; ADULTS; WOMEN; METABOLISM;

D O I：

10.1210/jc.2018-00850

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Context: In a previous community-based, cross-sectional study, males with type 1 diabetes (T1D) had lower bone mineral density (BMD) than did matched people without diabetes but females with T1D had normal BMD. Objective: To determine whether BMD in the males continued to decline, the neutral effect of T1D on BMD in females persisted, and whether temporal BMD changes reflected changes in bone turnover markers. Design: Longitudinal observational study. Setting: Urban community. Patients: Forty-eight of the original 102 original cross-sectional study participants (20 males, 28 females) of mean age 42.0 years and median diabetes duration 14.6 years at baseline who were restudied a mean of 10.3 years later. Main Outcome Measures: BMD at total hip, femoral neck, lumbar spine (L1 to L4), and distal forearm. Biochemical bone turnover markers. Results: After adjustment for age, body mass index (BMI), and renal function, there was no temporal change in BMD at the hip or forearm in the males (P >= 0.12), but lumbar spine BMD increased (P = 0.009). Females exhibited no statistically significant change in BMD in similar multivariable models that also included postmenopausal status, except a mild increase at the forearm (P = 0.046). Age- and sex-related changes in bone turnover markers paralleled those in general population studies. Conclusions: There is a reduction in BMD in males with T1D that occurs early in the course of the disease but then stabilizes. BMD in females with T1 D remains similar to that expected for age, BMI, and postmenopausal status.

引用

页码：3531 / 3539

页数：9