Mechanisms of Severe Mortality-Associated Bacterial Co-infections Following Influenza Virus Infection

被引：85

作者：

Jia, Leili ^{[1
]}

Xie, Jing ^{[1
]}

Zhao, Jiangyun ^{[1
]}

Cao, Dekang ^{[2
]}

Liang, Yuan ^{[1
]}

Hou, Xuexin ^{[3
]}

Wang, Ligui ^{[1
]}

Li, Zhenjun ^{[3
]}

机构：

[1] Chinese Peoples Liberat Army, Inst Dis Control & Prevent, Beijing, Peoples R China

[2] Chinese Peoples Armed Police Forces, Ctr Dis Control & Prevent, Beijing, Peoples R China

[3] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2017年 / 7卷

基金：

中国国家自然科学基金;

关键词：

co-infection; influenza; bacteria; resumption of function; tolerance; mortality; RESPIRATORY-TRACT INFECTION; ACTIVATING-FACTOR RECEPTOR; STREPTOCOCCUS-PNEUMONIAE; STAPHYLOCOCCUS-AUREUS; A VIRUS; I INTERFERONS; PNEUMOCOCCAL INFECTION; MENINGOCOCCAL DISEASE; ALVEOLAR MACROPHAGES; PANDEMIC INFLUENZA;

D O I：

10.3389/fcimb.2017.00338

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Influenza virus infection remains one of the largest disease burdens on humans. Influenza-associated bacterial co-infections contribute to severe disease and mortality during pandemic and seasonal influenza episodes. The mechanisms of severe morbidity following influenza bacteria co-infections mainly include failure of an antibacterial immune response and pathogen synergy. Moreover, failure to resume function and tolerance might be one of the main reasons for excessive mortality. In this review, recent advances in the study of mechanisms of severe disease, caused by bacterial co-infections following influenza virus pathogenesis, are summarized. Therefore, understanding the synergy between viruses and bacteria will facilitate the design of novel therapeutic approaches to prevent mortality associated with bacterial co-infections.

引用

页数：7

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