Optimization of line-field spectral domain optical coherence tomography for in vivo high-speed 3D retinal imaging

Line-field spectral domain optical coherence tomography (LF-SDOCT), which is a parallel detection OCT technique that provides single cross-sectional image without mechanical scanning, has been developed for very high-speed three-dimensional (313) imaging of human retina in vivo. By optimizing the integration time of the camera for the sample motion, we have successfully performed the in vivo 3D retinal imaging, which is sufficiently free from the motion artifact. The achievable A-lines rate is 54.4 kHz A-lines/s with the maximum sensitivity of 89.4 dB, and it corresponds to more than 2 times higher speed than conventional flying spot SD-OCT system. The in vivo 3D retinal measurement with the 256 cross-sectional images (528 A-lines/image) was successfully performed at 2.5 seconds.