Characterization of binding interaction of triclosan and bovine serum albumin

被引:7
作者
Wang, Xiaofang [1 ]
Zou, Luyi [1 ]
Mi, Chenyu [1 ]
Yu, Hongyan [1 ]
Dong, Mengxue [1 ]
Teng, Yue [1 ]
机构
[1] Jiangnan Univ, Sch Environm & Civil Engn, Jiangsu Key Lab Anaerob Biotechnol, Wuxi, Jiangsu, Peoples R China
来源
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING | 2020年 / 55卷 / 03期
基金
中国博士后科学基金;
关键词
Triclosan; bovine serum albumin; molecular docking simulation; binding mechanism; toxicity; PERSONAL CARE PRODUCTS; TRANSFORMATION PRODUCTS; COMPLEX; TRICLOCARBAN; INSIGHTS; WATER; ACID; DNA;
D O I
10.1080/10934529.2019.1694346
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Triclosan (TCS) is widely used in personal care products and acts as an antibacterial agent. Residues of TCS may have potential effects on the human health. In this article, the interaction between TCS and bovine serum albumin (BSA) has been characterized by using multi-spectroscopic approaches and molecular docking method under physiological conditions. Thermodynamic investigations revealed that TCS spontaneously bound to a binding site of BSA and hydrogen bonds played a dominant role in this process. The site marker competition experiments indicated that TCS bound at site II (subdomain IIIA) of BSA, which was well substantiated by molecular docking. The binding of TCS further led to changes of conformation and microenvironment of BSA. This work explored the interaction of TCS with BSA, which might be beneficial for evaluating the binding mechanism of other environmental pollutant at molecular level.
引用
收藏
页码:318 / 325
页数:8
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