Stromal issues in cervical cancer: a review of the role and function of basement membrane, stroma, immune response and angiogenesis in cervical cancer development

被引：20
作者：
Sahebali, Shaira [1 ,2 ]
Van den Eynden, Gert [3 ]
Murta, Eddie F. [5 ]
Michelin, Marcia A. [6 ]
Cusumano, Pino [4 ]
Petignat, Patrick [7 ]
Bogers, Johannes J. [1 ,2 ]
机构：
[1] Univ Antwerp, Appl Mol Res Grp AMBIOR, Cell Biol & Histol Lab, B-2020 Antwerp, Belgium
[2] Lab Clin Pathol Labo Lokeren Campus Riatol, Antwerp, Belgium
[3] Univ Antwerp, Translat Canc Res Grp, Pathol Lab, Univ Antwerp Hosp,Oncol Ctr,Gen Hosp St Augustinu, B-2020 Antwerp, Belgium
[4] Dept Obstet & Gynecol, Surg Gynecol Oncol Unit, Liege, Belgium
[5] Univ Fed Triangulo Mineiro, Res Inst Oncol IPON Gynecol & Obstet, Uberaba, MG, Brazil
[6] Univ Fed Triangulo Mineiro, Res Inst Oncol IPON, Uberaba, MG, Brazil
[7] Univ Hosp Geneva, Dept Obstet & Gynecol, Surg Gynecol Oncol Unit, Geneva, Switzerland
来源：
EUROPEAN JOURNAL OF CANCER PREVENTION | 2010年 / 19卷 / 03期
关键词：
angiogenesis; cervical carcinoma; human papillomavirus; immune response; stroma; ENDOTHELIAL GROWTH-FACTOR; SQUAMOUS-CELL CARCINOMA; HUMAN-PAPILLOMAVIRUS TYPE-16; LAMININ-5; GAMMA-2; CHAIN; THYMIDINE PHOSPHORYLASE EXPRESSION; LYMPHATIC MICROVESSEL DENSITY; MESSENGER-RNA EXPRESSION; FACTOR-C EXPRESSION; MATRIX METALLOPROTEINASES; TUMOR ANGIOGENESIS;
D O I：
10.1097/CEJ.0b013e32833720de
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The carcinogenesis of cervical carcinoma implies an intricate interplay of neoplastic, human papillomavirus infected epithelial cells and stromal tissue, in which different factors have distinct but interacting influence. Persistent infection with an oncogenic human papillomavirus type may lead to epithelial dysplasia with progressive severity. To access the adjacent stromal tissue, tumour cells have to breach the basement membrane. The stroma partly controls tumour growth, invasion and angiogenesis. Last but not least there is considerable influence of the immune response. In this review we describe the importance of various stromal factors in carcinogenesis of cervical cancer. European Journal of Cancer Prevention 19:204-215 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
引用
收藏
页码：204 / 215
页数：12
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