Biological evaluation of certain substituted hydantoins and benzalhydantoins against microbes

被引：9
作者：
Hidayat, Ika-Wiani [1 ,2 ]
Thu, Yee Yee [2 ,3 ]
Black, David St C. [2 ]
Read, Roger W. [2 ]
机构：
[1] Padjadjaran State Univ, Dept Chem, Jl Raya Bandung Sumedang Km 21, Jatinangor 45363, Indonesia
[2] Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia
[3] Univ Yangon, Dept Bot, Yangon, Myanmar
来源：
10TH JOINT CONFERENCE ON CHEMISTRY | 2016年 / 107卷
关键词：
ANTIFUNGAL AGENTS; IN-VITRO; RESISTANT; METHICILLIN; ENTEROCOCCI; DERIVATIVES;
D O I：
10.1088/1757-899X/107/1/012058
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Twenty-three synthetic (thio)hydantoins and benzalhydantoins were evaluated for antimicrobial activity against Candida albicans, Malassezia furfur, Escherichia coli and Staphylococcus aureus, by the paper disc diffusion method. 3-n-butyl-4'-nitrobenzalhydantoin showed very high activity against E. coli and high selectivity with respect to the other microorganisms, while 3-n-butyl-2'-bromo-4', 5'-dimethoxybenzal hydantoin demonstrated very high selectivity in its activity against M. furfur and S. aureus. These compounds show the most promise as drug lead compounds.
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页数：7
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