Is Colectomy Associated with the Risk of Type 2 Diabetes in Patients without Colorectal Cancer? A Population-Based Cohort Study

被引：3

作者：

Wu, Chin-Chia ^{[1
,2
]}

Lee, Cheng-Hung ^{[2
,3
]}

Hsu, Ta-Wen ^{[1
,4
]}

Yeh, Chia-Chou ^{[2
,5
]}

Lin, Mei-Chen ^{[6
,7
]}

Chang, Chun-Ming ^{[4
,8
]}

Tsai, Jui-Hsiu ^{[4
,9
,10
,11
]}

机构：

[1] Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Div Colorectal Surg, Chiayi 622, Taiwan

[2] Tzu Chi Univ, Sch Postbaccalaureate Chinese Med, Hualien 970, Taiwan

[3] Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Div Gen Surg, Chiayi 622, Taiwan

[4] Tzu Chi Univ, Coll Med, Hualien 970, Taiwan

[5] Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Chinese Med, Chiayi 622, Taiwan

[6] China Med Univ Hosp, Management Off Hlth Data, Taichung 404, Taiwan

[7] China Med Univ, Coll Med, Taichung 404, Taiwan

[8] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Gen Surg, Hualien 970, Taiwan

[9] Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Psychiat, Chiayi 622, Taiwan

[10] Natl Hlth Res Inst, PhD Program Environm & Occupat Med, Kaohsiung 807, Taiwan

[11] Kaohsiung Med Univ, Kaohsiung 807, Taiwan

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 22期

关键词：

colectomy; type; 2; diabetes; cohort study; GUT MICROBIOTA; WEIGHT-GAIN; HYPERTENSION; INFLAMMATION; PREVALENCE; MELLITUS; TAIWAN; HEALTH; GLP-1; HYPERGLYCEMIA;

D O I：

10.3390/jcm10225313

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes might be influenced by colonic disease; however, the association between colonic resection and type 2 diabetes has rarely been discussed. This population-based cohort study explored the association between colectomy and type 2 diabetes in patients without colorectal cancer. A total of 642 patients who underwent colectomy for noncancerous diseases at any time between 2000 and 2012 in the National Health Insurance Research Database of Taiwan were enrolled. The enrolled patients were matched with 2568 patients without colectomy at a 1:4 ratio using a propensity score that covered age, sex, and comorbidities. The risk of type 2 diabetes was assessed using a Cox proportional hazards model. The mean (standard deviation) follow-up durations in colectomy cases and non-colectomy controls were 4.9 (4.0) and 5.6 (3.6) years, respectively; 65 (10.1%) colectomy cases and 342 (15.5%) non-colectomy controls developed type 2 diabetes. After adjustment, colectomy cases still exhibited a decreased risk of type 2 diabetes (adjusted HR = 0.80, 95% CI: 0.61-1.04). A stratified analysis for colectomy type indicated that patients who underwent right or transverse colectomy had a significantly lower risk of developing type 2 diabetes (adjusted HR = 0.57, 95% CI: 0.34-0.98). In the present study, colectomy tended to be at a reduced risk of type 2 diabetes in patients without colorectal cancer, and right or transverse colectomies were especially associated with a significantly reduced risk of type 2 diabetes.

引用

页数：11

共 65 条

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