AMPK mediates autophagy during myocardial ischemia in vivo

被引：148

作者：

Takagi, Hiromitsu

Matsui, Yutaka

Hirotani, Shinichi

Sakoda, Hideyuki

Asano, Tomoichiro

Sadoshima, Junichi

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Cardiovasc Res Inst, Dept Cell Biol & Mol Med, Newark, NJ 07103 USA

[2] Univ Tokyo, Grad Sch Med, Dept Internal Med, Tokyo, Japan

[3] Hiroshima Univ, Div Mol Med Sci, Hiroshima, Japan

来源：

AUTOPHAGY | 2007年 / 3卷 / 04期

关键词：

ischemia; reperfusion; AMPK; autophagy; heart; beclin1;

D O I：

10.4161/auto.4281

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo.

引用

页码：405 / 407

页数：3

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