Selective loss of regulatory T cells in thymomas

被引：68
作者：
Ströbel, P
Rosenwald, A
Beyersdorf, N
Kerkau, T
Elert, O
Murumägi, A
Sillanpää, N
Peterson, P
Hummel, V
Rieckmann, P
Burek, C
Schalke, B
Nix, W
Kiefer, R
Müller-Hermelink, HK
Marx, A
机构：
[1] Univ Wurzburg, Inst Pathol, D-97080 Wurzburg, Germany
[2] Univ Wurzburg, Inst Virol, Wurzburg, Germany
[3] Univ Wurzburg, Dept Cardiac & Thorac Surg, Wurzburg, Germany
[4] Univ Wurzburg, Dept Neurol, Wurzburg, Germany
[5] Univ Tampere, Inst Med Technol, FIN-33101 Tampere, Finland
[6] Univ Regensburg, Dept Neurol, D-8400 Regensburg, Germany
[7] Univ Mainz, Dept Neurol, D-6500 Mainz, Germany
[8] Univ Munster, Dept Neurol, Munster, Germany
来源：
ANNALS OF NEUROLOGY | 2004年 / 56卷 / 06期
关键词：
D O I：
10.1002/ana.20340
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Myasthenia gravis (MG) is the prime autoimmune manifestation of thymomas. We investigated the generation of T cells with a regulatory phenotype (T-R) in thymomas with and without associated MG. In patients with MG(+) thymomas, maturation and export of T-R cells but not of other T-cell subsets was significantly reduced. We conclude that imbalance between effector and regulatory T cells in thymomas may be involved in modulation of onset and/or severity of MG.
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页码：901 / 904
页数：4
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