Changes in gene body methylation do not correlate with changes in gene expression in Anthozoa or Hexapoda

被引:26
作者
Dixon, Groves [1 ]
Matz, Mikhail [1 ]
机构
[1] Univ Texas Austin, Dept Integrat Biol, Austin, TX 78712 USA
基金
美国国家科学基金会;
关键词
Epigenetics; DNA methylation; Gene regulation; Plasticity; Transcriptomics; Gene body methylation; Coral; DNA METHYLATION; EVOLUTIONARY CONSEQUENCES; GENOME;
D O I
10.1186/s12864-022-08474-z
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background As human activity alters the planet, there is a pressing need to understand how organisms adapt to environmental change. Of growing interest in this area is the role of epigenetic modifications, such as DNA methylation, in tailoring gene expression to fit novel conditions. Here, we reanalyzed nine invertebrate (Anthozoa and Hexapoda) datasets to validate a key prediction of this hypothesis: changes in DNA methylation in response to some condition correlate with changes in gene expression. Results In accord with previous observations, baseline levels of gene body methylation (GBM) positively correlated with transcription, and negatively correlated with transcriptional variation between conditions. Correlations between changes in GBM and transcription, however, were negligible. There was also no consistent negative correlation between methylation and transcription at the level of gene body methylation class (either highly- or lowly-methylated), anticipated under the previously described "seesaw hypothesis". Conclusion Our results do not support the direct involvement of GBM in regulating dynamic transcriptional responses in invertebrates. If changes in DNA methylation regulate invertebrate transcription, the mechanism must involve additional factors or regulatory influences.
引用
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页数:11
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