Sex differences in the blood-brain barrier and neurodegenerative diseases

被引：50

作者：

Weber, Callie M. ^{[1
]}

Clyne, Alisa Morss ^{[1
]}

机构：

[1] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA

来源：

APL BIOENGINEERING | 2021年 / 5卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Alzheimer's disease - Biological variables - Blood-brain barrier - Motor neuron disease - Multiple sclerosis - Parkinson's disease - Potential mechanism - Sex-related differences;

D O I：

10.1063/5.0035610

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The number of people diagnosed with neurodegenerative diseases is on the rise. Many of these diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and motor neuron disease, demonstrate clear sexual dimorphisms. While sex as a biological variable must now be included in animal studies, sex is rarely included in in vitro models of human neurodegenerative disease. In this Review, we describe these sex-related differences in neurodegenerative diseases and the blood-brain barrier (BBB), whose dysfunction is linked to neurodegenerative disease development and progression. We explain potential mechanisms by which sex and sex hormones affect BBB integrity. Finally, we summarize current in vitro BBB bioengineered models and highlight their potential to study sex differences in BBB integrity and neurodegenerative disease.

引用

页数：12