Pax6 controls progenitor cell identity and neuronal fate in response to graded shh signaling

被引：830
作者：
Ericson, J
Rashbass, P
Schedl, A
BrennerMorton, S
Kawakami, A
vanHeyningen, V
Jessell, TM
Briscoe, J
机构：
[1] COLUMBIA UNIV,DEPT BIOCHEM & MOL BIOPHYS,HOWARD HUGHES MED INST,NEW YORK,NY 10032
[2] WESTERN GEN HOSP,MRC,HUMAN GENET UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND
[3] NAGOYA UNIV,DIV BIOL SCI,NAGOYA,AICHI 46401,JAPAN
来源：
CELL | 1997年 / 90卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S0092-8674(00)80323-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.
引用
收藏
页码：169 / 180
页数：12
相关论文
共 52 条
  • [21] EARLY DEVELOPMENT OF THE HYPOGLOSSAL NERVE IN THE CHICK-EMBRYO AS OBSERVED BY THE WHOLE-MOUNT NERVE STAINING METHOD
    KURATANI, S
    TANAKA, S
    ISHIKAWA, Y
    ZUKERAN, C
    [J]. AMERICAN JOURNAL OF ANATOMY, 1988, 182 (02): : 155 - 168
  • [22] GSH-4 ENCODES A LIM-TYPE HOMEODOMAIN, IS EXPRESSED IN THE DEVELOPING CENTRAL-NERVOUS-SYSTEM AND IS REQUIRED FOR EARLY POSTNATAL SURVIVAL
    LI, H
    WITTE, DP
    BRANFORD, WW
    ARONOW, BJ
    WEINSTEIN, M
    KAUR, S
    WERT, S
    SINGH, G
    SCHREINER, CM
    WHITSETT, JA
    SCOTT, WJ
    POTTER, SS
    [J]. EMBO JOURNAL, 1994, 13 (12) : 2876 - 2885
  • [23] DORSAL DIFFERENTIATION OF NEURAL PLATE CELLS INDUCED BY BMP-MEDIATED SIGNALS FROM EPIDERMAL ECTODERM
    LIEM, KF
    TREMML, G
    ROELINK, H
    JESSELL, TM
    [J]. CELL, 1995, 82 (06) : 969 - 979
  • [24] Liinamaa TL, 1997, J COMP NEUROL, V377, P298, DOI 10.1002/(SICI)1096-9861(19970113)377:2<298::AID-CNE10>3.0.CO
  • [25] 2-N
  • [26] DEVELOPMENTAL EXPRESSION OF A NOVEL MURINE HOMEOBOX GENE (CHX10) - EVIDENCE FOR ROLES IN DETERMINATION OF THE NEURORETINA AND INNER NUCLEAR LAYER
    LIU, ISC
    CHEN, JD
    PLODER, L
    VIDGEN, D
    VANDERKOOY, D
    KALNINS, VI
    MCINNES, RR
    [J]. NEURON, 1994, 13 (02) : 377 - 393
  • [27] MOUSE HOMEOBOX GENE DBX - SEQUENCE, GENE STRUCTURE AND EXPRESSION PATTERN DURING MIDGESTATION
    LU, SW
    WISE, TL
    RUDDLE, FH
    [J]. MECHANISMS OF DEVELOPMENT, 1994, 47 (02) : 187 - 195
  • [28] MACDONALD R, 1995, DEVELOPMENT, V121, P3267
  • [29] REQUIREMENT OF 19K FORM OF SONIC HEDGEHOG FOR INDUCTION OF DISTINCT VENTRAL CELL-TYPES IN CNS EXPLANTS
    MARTI, E
    BUMCROT, DA
    TAKADA, R
    MCMAHON, AP
    [J]. NATURE, 1995, 375 (6529) : 322 - 325
  • [30] OSUMI N, 1997, IN PRESS DEVELOPMENT
123456