Pax6 controls progenitor cell identity and neuronal fate in response to graded shh signaling

被引：831
作者：
Ericson, J
Rashbass, P
Schedl, A
BrennerMorton, S
Kawakami, A
vanHeyningen, V
Jessell, TM
Briscoe, J
机构：
[1] COLUMBIA UNIV,DEPT BIOCHEM & MOL BIOPHYS,HOWARD HUGHES MED INST,NEW YORK,NY 10032
[2] WESTERN GEN HOSP,MRC,HUMAN GENET UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND
[3] NAGOYA UNIV,DIV BIOL SCI,NAGOYA,AICHI 46401,JAPAN
来源：
CELL | 1997年 / 90卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S0092-8674(00)80323-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.
引用
收藏
页码：169 / 180
页数：12
相关论文
共 52 条
[1]  
BARTH KA, 1995, DEVELOPMENT, V121, P1755
[2]   QUANTITATIVE-ANALYSIS OF CERVICAL MUSCULATURE IN RATS - HISTOCHEMICAL COMPOSITION AND MOTOR POOL ORGANIZATION .2. DEEP DORSAL MUSCLES [J].
CALLISTER, RJ ;
BRICHTA, AM ;
PETERSON, EH .
JOURNAL OF COMPARATIVE NEUROLOGY, 1987, 255 (03) :369-385
[3]   Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function [J].
Chiang, C ;
Ying, LTT ;
Lee, E ;
Young, KE ;
Corden, JL ;
Westphal, H ;
Beachy, PA .
NATURE, 1996, 383 (6599) :407-413
[4]  
DAVIS CA, 1991, DEVELOPMENT, V111, P287
[5]   SPATIAL REGULATION OF AXONAL GLYCOPROTEIN EXPRESSION ON SUBSETS OF EMBRYONIC SPINAL NEURONS [J].
DODD, J ;
MORTON, SB ;
KARAGOGEOS, D ;
YAMAMOTO, M ;
JESSELL, TM .
NEURON, 1988, 1 (02) :105-116
[6]   PATTERNING ACTIVITIES OF VERTEBRATE HEDGEHOG PROTEINS IN THE DEVELOPING EYE AND BRAIN [J].
EKKER, SC ;
UNGAR, AR ;
GREENSTEIN, P ;
VONKESSLER, DP ;
PORTER, JA ;
MOON, RT ;
BEACHY, PA .
CURRENT BIOLOGY, 1995, 5 (08) :944-955
[7]   Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identify [J].
Ericson, J ;
Morton, S ;
Kawakami, A ;
Roelink, H ;
Jessell, TM .
CELL, 1996, 87 (04) :661-673
[8]   SONIC HEDGEHOG INDUCES THE DIFFERENTIATION OF VENTRAL FOREBRAIN NEURONS - A COMMON SIGNAL FOR VENTRAL PATTERNING WITHIN THE NEURAL-TUBE [J].
ERICSON, J ;
MUHR, J ;
PLACZEK, M ;
LINTS, T ;
JESSELL, TM ;
EDLUND, T .
CELL, 1995, 81 (05) :747-756
[9]  
ERICSON J, 1992, SCIENCE, V256, P1550
[10]   Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of down syndrome [J].
Fan, CM ;
Kuwana, E ;
Bulfone, A ;
Fletcher, CF ;
Copeland, NG ;
Jenkins, NA ;
Crews, S ;
Martinez, S ;
Puelles, L ;
Rubenstein, JLR ;
TessierLavigne, M .
MOLECULAR AND CELLULAR NEUROSCIENCE, 1996, 7 (01) :1-16
123456