Triterpenoids and phenolics from the fruiting bodies of Inonotus hispidus and their activations of melanogenesis and tyrosinase

被引：25

作者：

Ren, Qing ^{[1
,2
]}

Lu, Xue-Ying ^{[1
]}

Han, Jian-Xin ^{[1
,2
]}

Aisa, Haji Akber ^{[1
]}

Yuan, Tao ^{[1
]}

机构：

[1] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Xinjiang Indigenous Med Plants Reso, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2017年 / 28卷 / 05期

关键词：

Inonotus hispidus; Lanostane triterpenoids; Phenolic compound; Melanogenesis; Tyrosinase; DERIVATIVES; MUSHROOMS; ACID;

D O I：

10.1016/j.cclet.2016.12.010

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new 24-methyl lanostane triterpenoids, hispindic acids A and B (1 and 2), and a new phenolic compound, hispinine (7), along with nine known compounds (3-6, and 8-12), were isolated from the fruiting bodies of Inonotus hispidus. Their structures were elucidated based on the extensive analysis of spectroscopic data (NMR and HRMS). Hispindic acid A (1) possesses an unusual formyl group at C-30. Compounds 1, 3-4, and 8 showed stronger activate abilities of melanogenesis and tyrosinase in B16 melanoma cells than those of positive control, 8-methoxypsoralen, at 50 mu mol/L. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：1052 / 1056

页数：5

共 13 条

[1] Antiviral activity of Inonotus hispidus [J].