Some endogenous retroviral sequences in the human genome can play a physiological or pathological role

被引：4
作者：
Medina, Julie [1 ]
Charvet, Benjamin [2 ,3 ,4 ,5 ,6 ,7 ]
Leblanc, Pascal [6 ,8 ]
Germi, Raphaele [9 ,10 ]
Horvat, Branka [2 ,3 ,4 ,5 ,6 ,7 ]
Marche, Patrice N. [11 ,12 ]
Perron, Herve [1 ,5 ,13 ]
机构：
[1] GeNeuro Innovat, Bioparc Laennec,60,Ave Rockefeller, F-69008 Lyon, France
[2] CIRI, Lyon, France
[3] INSERM, U1111, Lyon, France
[4] CNRS, UMR5308, Lyon, France
[5] Univ Lyon 1, Fac Med Laennec, F-69008 Lyon, France
[6] Ecole Normale Super Lyon, INSERM, Inst NeuroMyogene INMG, CNRS,UMR5310,U1217,LBMC, Lyon, France
[7] ECOFECT, Lab Excellence, Lyon, France
[8] Univ Lyon 1, CNRS, ENS, UMR 5239, Lyon, France
[9] CHU Grenoble, Inst Biol & Pathol, Virol Lab, Grenoble, France
[10] UGA, CNRS, CEA, Inst Biol Struct,UMR 5075, Grenoble, France
[11] INSERM, U1209, Grenoble, France
[12] Univ Grenoble Alpes, CNRS, UMR5309, Inst Adv Biosci, Grenoble, France
[13] GeNeuro, 18 Chemin Aulx, CH-1228 Geneva, Switzerland
来源：
M S-MEDECINE SCIENCES | 2017年 / 33卷 / 04期
关键词：
AMYOTROPHIC-LATERAL-SCLEROSIS; LONG TERMINAL REPEAT; MULTIPLE-SCLEROSIS; ENVELOPE PROTEIN; HERV-W; REVERSE-TRANSCRIPTASE; IN-VITRO; EXPRESSION; SUPERANTIGEN; TDP-43;
D O I：
10.1051/medsci/20173304009
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Human endogenous retroviruses (HERV) represent a large part of our genome and the few elements that have retained a potential of expression still remain "dormant" in physiological conditions. In some instances, they can be awakened by environmental factors activating their expression. The best studied conditions of HERV activation are infections caused by microorganisms such as viruses of the Herpesvirus family. This activation can thus lead to the expression of pathogenic proteins such as envelope proteins belonging to the HERV-W and HERV-K families, respectively involved in Multiple Sclerosis (MS) and amyotrophic lateral sclerosis (ALS). Endogenous retroviral proteins can also acquire a physiological function beneficial for humans. This is the case of Syncytin-1 from the HERV-W family, that is involved in placenta formation. © 2017 médecine/sciences-Inserm.
引用
收藏
页码：397 / 403
页数：7
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