Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat

被引：49

作者：

Chapman, V ^{[1
]}

Diaz, A ^{[1
]}

Dickenson, AH ^{[1
]}

机构：

[1] UCL, Dept Pharmacol, London WC1E 6BT, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1997年 / 122卷 / 08期

基金：

英国惠康基金;

关键词：

antinociception; endomorphin-1; endomorphin-2; intrathecal; spinal neurones;

D O I：

10.1038/sj.bjp.0701594

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intrathecal endomorphin-1 and endomorphin-2 (0.25-50 mu g) dose-relatedly reduced all components of electrical evoked C-fibre responses of spinal neurones. These effects were partially reversed by naloxone. Endomorphin-1, but not endomorphin-2, dose-relatedly reduced the A beta-fibre evoked responses. Peak inhibitory effects of endomorphin-1 and -2 were at 15-20 min post-administration. Thus spinal endomorphin-2 had selective effects on noxious responses, whereas endomorphin-1 was non-selective.

引用

页码：1537 / 1539

页数：3