Electrospun composite nanofiber membrane of poly(L-lactide) and surface grafted chitin whiskers: Fabrication, mechanical properties and cytocompatibility

被引：57

作者：

Liu, Hua ^{[1
]}

Liu, Wenjun ^{[1
]}

Luo, Binghong ^{[1
,2
]}

Wen, Wei ^{[1
]}

Liu, Mingxian ^{[1
,2
]}

Wang, Xiaoying ^{[3
]}

Zhou, Changren ^{[1
,2
]}

机构：

[1] Jinan Univ, Coll Sci & Engn, Dept Mat Sci & Engn, Biomat Res Lab, Guangzhou 510632, Guangdong, Peoples R China

[2] Minist Educ, Engn Res Ctr Artificial Organs & Mat, Guangzhou 510632, Guangdong, Peoples R China

[3] Jinan Univ, Coll Life Sci & Technol, Dept Biomed Engn, Guangzhou 510632, Guangdong, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2016年 / 147卷

基金：

中国国家自然科学基金;

关键词：

Poly(L-lactide); Chitin whisker; Surface modification; Electrospinning; Mechanical properties; Cytocompatibility; BIODEGRADABLE POLYMERS;

D O I：

10.1016/j.carbpol.2016.03.096

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

To improve both the mechanical properties and cytocompatibility of poly(L-lactide) (PLLA), rod-like chitin whiskers (CHWs) were prepared, and subsequently surface modified with L-lactide to obtain grafted CHWs (g-CHWs). Then, CHWs and g-CHWs were further introduced into PLLA matrix to fabricate CHWs/PLLA and g-CHWs/PLLA nanofiber membranes by electrospinning technique. Morphologies and properties of the CHWs and g-CHWs were characterized. The surface-grafted PLLA chains played an important role in improving interfacial interaction between the whiskers and PLLA matrix. The g-CHWs dispersed more uniformly in matrix than CHWs, and the as-prepared g-CHWs/PLLA nanofiber membrane showed relative smooth and uniform fiber. As a result, the tensile strength and modulus of the g-CHWs/PLLA nanofiber membrane were obviously superior to those of the pure PLLA and CHWs/PLLA nanofiber membranes. Cells culture results indicated that g-CHWs/PLLA nanofiber membrane is more effectively in promoting MC3T3-E1 cells adhesion, spreading and proliferation than pure PLLA and CHWs/PLLA nanofiber membrane. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：216 / 225

页数：10

共 35 条

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