Regioselective diarylation of ketone enolates by homogeneous and heterogeneous catalysis:: synthesis of triarylethanones

被引：28
作者：
Churruca, F [1 ]
SanMartin, R [1 ]
Tellitu, I [1 ]
Domínguez, E [1 ]
机构：
[1] Euskal Herriko Unibertsitatea, Zientzi Fak, Kim Organ Saila 2, Bilbao 48080, Spain
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 31期
关键词：
arylation; ketones; palladium and compounds;
D O I：
10.1016/S0040-4039(03)01398-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel, one-step approach to 1,2,2-triarylethanones is achieved by an efficient palladium-catalyzed alpha,alpha-diarylation of commercially available acetophenones. After assaying an array of experimental conditions, two convenient procedures, which avoid ortho-arylation side reactions, are chosen to perform the target regioselective diarylation. The former protocol is based on the use of such a simple homogeneous system as Pd(OAc)(2)/PPh3/Cs2CO3, and the latter one employs a commercially available polymer-anchored catalyst. FibreCat(TM) 1026. (C) 2003 Elsevier Ltd. All rights reserved.
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收藏
页码：5925 / 5929
页数：5
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