Genetic association studies in cardiovascular diseases: Do we have enough power?

被引：10

作者：

Auer, Paul L. ^{[1
]}

Stitziel, Nathan O. ^{[2
,3
,4
]}

机构：

[1] Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA

[2] Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, McDonnell Genome Inst, St Louis, MO USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2017年 / 27卷 / 06期

关键词：

GWAS; Genetics; Power; GENOME-WIDE ASSOCIATION; LOW-FREQUENCY; RARE VARIANTS; COMMON; PCSK9; STRATIFICATION; METAANALYSIS; REPLICATION; PROTECTION; MUTATIONS;

D O I：

10.1016/j.tcm.2017.03.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genetic association studies have a long history of delivering insightful results for cardiovascular disease (CVD) research. Beginning with early candidate gene studies, to genome-wide association studies, and now on to newer whole-genome sequencing studies, research in human genetics has enriched our understanding of the pathobiology of CVD. As these studies continue to expand, the issue of statistical power plays an important role in study design as well as the interpretation of results. We provide an overview of the component parts that determine statistical power and preview the future of CVD genetic association studies through this lens.

引用

页码：397 / 404

页数：8

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