Efficacy and safety of direct-acting antiviral therapy in previous hard-to-treat patients with recurrent hepatitis C virus infection after liver transplantation: a real-world cohort

被引：8

作者：

Bernuth, Sebastian ^{[1
]}

Grimm, Daniel ^{[1
]}

Vollmar, Johanna ^{[1
]}

Darstein, Felix ^{[1
]}

Mittler, Jens ^{[2
]}

Heise, Michael ^{[2
]}

Hoppe-Lotichius, Maria ^{[2
]}

Galle, Peter R. ^{[1
]}

Lang, Auke ^{[2
]}

Zimmermann, Tim ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Internal Med 1, Transplant Hepatol, Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Gen Abdominal & Transplant Surg, Mainz, Germany

来源：

DRUG DESIGN DEVELOPMENT AND THERAPY | 2017年 / 11卷

关键词：

HCV; DAA; liver transplantation; reinfection; sustained virological response; SVR; SOFOSBUVIR-BASED TREATMENT; TREATMENT-NAIVE PATIENTS; GENOTYPE; NATURAL-HISTORY; HCV INFECTION; RISK-FACTORS; DONOR AGE; RIBAVIRIN; CIRRHOSIS; INTERFERON;

D O I：

10.2147/DDDT.S139837

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Background: Recurrent hepatitis C virus (HCV) infection after liver transplantation (LT) has been a frequent and relevant problem in the past two decades. This analysis evaluated the efficacy and safety of new interferon (IFN)-free direct-acting antiviral (DAA) therapies in a large real-world cohort of HCV patients after LT. Methods: We retrospectively analyzed a cohort of 157 patients infected with HCV who underwent deceased donor LT between 1997 and 2014. Patient survival, outcome, and side effects of antiviral therapy were assessed. Results: Survival with recurrent HCV genotype 1 (GT1) infection was inferior to other HCV GTs (P= 0.01). The overall sustained virological response (SVR) rate with new DAA therapy was 94.6% (n= 37). Patients with both GT1 and other GTs reached SVR rates.90%. We noticed a few side effects, mainly caused by ribavirin, and only one discontinuation in DAA-treated patients. Conclusion: DAA therapy was effective and safe in previous hard-to-treat patients after LT in this real-world cohort.

引用

页码：2131 / 2138

页数：8

共 43 条

[1] Liver Transplantation and Hepatitis C [J].