Retinal nerve fibre layer thickness correlates with brain white matter damage in multiple sclerosis: A combined optical coherence tomography and diffusion tensor imaging study

被引：31

作者：

Scheel, Michael ^{[1
]}

Finke, Carsten ^{[2
]}

Oberwahrenbrock, Timm ^{[3
]}

Freing, Alina ^{[4
]}

Pech, Luisa-Maria ^{[3
]}

Schlichting, Jeremias ^{[3
]}

Soemmer, Carina ^{[3
]}

Wuerfel, Jens ^{[3
,4
]}

Paul, Friedemann ^{[2
,3
]}

Brandt, Alexander U. ^{[3
]}

机构：

[1] Charite, Inst Neuroradiol, D-10117 Berlin, Germany

[2] Charite, D-10117 Berlin, Germany

[3] Charite, NeuroCure Clin Res Ctr, D-10117 Berlin, Germany

[4] Univ Med Gottingen, Inst Intervent & Diagnost Neuroradiol, Gottingen, Germany

来源：

MULTIPLE SCLEROSIS JOURNAL | 2014年 / 20卷 / 14期

关键词：

Multiple sclerosis; optical coherence tomography; diffusion tensor imaging; optic nerve; optic radiation; retina; VISUAL DISABILITY; ASSOCIATION; RADIATION; NEURITIS;

D O I：

10.1177/1352458514535128

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the association of retinal nerve fibre layer thickness (RNFL) with white matter damage assessed by diffusion tensor imaging (DTI). Forty-four MS patients and 30 healthy subjects underwent optical coherence tomography. DTI was analysed with a voxel-based whole brain and region-based analysis of optic radiation, corpus callosum and further white matter. Correlations between RNFL, fractional anisotropy (FA) and other DTI-based parameters were assessed in patients and controls. RNFL correlated with optic radiation FA, but also with corpus callosum and remaining white matter FA. Our findings demonstrate that RNFL changes indicate white matter damage exceeding the visual pathway.

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收藏

页码：1904 / 1907

页数：4

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