Is amine addition vital for highly enantioselective hydrogenation of α,β-unsaturated carboxylic acid over cinchonidine-modified palladium?

被引：24
作者：
Kim, Tae Yeon [1 ]
Sugimura, Takashi [1 ]
机构：
[1] Univ Hyogo, Grad Sch Mat Sci, Kamigori, Hyogo 6781297, Japan
来源：
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2010年 / 327卷 / 1-2期
关键词：
Pd/C; Enantioselectivity; Hydrogenation; Unsaturated acid; Additive; ASYMMETRIC HYDROGENATION; (E)-ALPHA-PHENYLCINNAMIC ACID; MODIFIED PD/TIO2; CARBON; PD/C; CATALYSTS; OLEFINS; TIO2;
D O I：
10.1016/j.molcata.2010.05.013
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Benzylamine (BA) is a commonly employed additive for the hydrogenation of alpha,beta-unsaturated acids over the cinchonidine-modified palladium catalyst, but the BA addition effects largely depend on the reaction solvent. In toluene, BA is not required to obtain the high enantioselectivity. Quicker desorption of the product due to weaker acidity in toluene than in a commonly used wet dioxane reasonably explains both the kinetic properties and the product selectivities. (C) 2010 Elsevier B.V. All rights reserved.
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页码：58 / 62
页数：5
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