Novel metabolism of docosahexaenoic acid in neural cells

被引:166
作者
Kim, Hee-Yong [1 ]
机构
[1] NIAAA, Div Intramural Clin & Biol Res, Mol Signalling Lab, Bethesda, MD 20892 USA
关键词
D O I
10.1074/jbc.R700015200
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Long-chain polyunsaturated fatty acids are highly enriched in the nervous system. Docosahexaenoic acid (DHA(2); 22: 6n-3), in particular, is the most abundant polyunsaturated fatty acid in the brain and is concentrated in aminophospholipids of cell membranes. Numerous studies have indicated that this concentration of DHA in the nervous system is essential for optimal neuronal and retinal functions (1). Although the underlying mechanisms of its essential function are still not clearly understood, emerging evidence suggests that unique metabolism of DHA in relation to its incorporation into neuronal membrane phospholipids plays an important role. In this review, biochemical mechanisms for enriching and metabolizing DHA in neural cells are discussed in the context of their biological significance in neuronal function.
引用
收藏
页码:18661 / 18665
页数:5
相关论文
共 57 条
[11]   Mobilization of arachidonate and docosahexaenoate by stimulation of the 5-HT2A receptor in rat C6 glioma cells [J].
Garcia, MC ;
Kim, HY .
BRAIN RESEARCH, 1997, 768 (1-2) :43-48
[12]  
GORACCI G, 1973, J NEUROCHEM, V20, P1167, DOI 10.1111/j.1471-4159.1973.tb00086.x
[13]  
GUO M, 2007, IN PRESS J MOL NEURO
[14]   n-3 fatty acid deficiency decreases phosphatidylserine accumulation selectively in neuronal tissues [J].
Hamilton, J ;
Greiner, R ;
Salem, N ;
Kim, HY .
LIPIDS, 2000, 35 (08) :863-869
[15]  
HARRIS RA, 1984, MOL PHARMACOL, V25, P401
[16]   PRESENCE OF BASE-EXCHANGE ACTIVITY IN RAT-BRAIN NERVE-ENDINGS - DEPENDENCE ON SOLUBLE SUBSTRATE CONCENTRATIONS AND EFFECT OF CATIONS [J].
HOLBROOK, PG ;
WURTMAN, RJ .
JOURNAL OF NEUROCHEMISTRY, 1988, 50 (01) :156-162
[17]   Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells -: Autacoids in anti-inflammation [J].
Hong, S ;
Gronert, K ;
Devchand, PR ;
Moussignac, RL ;
Serhan, CN .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (17) :14677-14687
[18]   Regulation of fatty acid transport [J].
Kalant, D ;
Cianflone, K .
CURRENT OPINION IN LIPIDOLOGY, 2004, 15 (03) :309-314
[19]  
KAMP F, 2006, PROSTAGLANDINS LEUKO, V75, P9
[20]   Determination of substrate preference in phosphatidylserine decarboxylation by liquid chromatography-electrospray ionization mass spectrometry [J].
Kevala, JH ;
Kim, HY .
ANALYTICAL BIOCHEMISTRY, 2001, 292 (01) :130-138