A Single-Blind, Parallel Design RCT to Assess the Effectiveness of SMS Reminders in Improving ART Adherence Among Adolescents Living with HIV (STARTA Trial)

被引：30

作者：

Abiodun, Olumide ^{[1
]}

Ladi-Akinyemi, Babatunde ^{[2
]}

Olu-Abiodun, Oluwatosin ^{[3
]}

Sotunsa, John ^{[4
]}

Bamidele, Fikayo ^{[5
]}

Adepoju, Akinmade ^{[5
]}

David, Nkiru ^{[6
]}

Adekunle, Motunrayo ^{[7
]}

Ogunnubi, Adetutu ^{[8
]}

Imhonopi, Gloria ^{[9
]}

Yinusa, Idayat ^{[10
]}

Erinle, Charles ^{[11
]}

Soetan, Olufemi ^{[12
]}

Arifalo, Gregory ^{[13
]}

Adeyanju, Olusoji ^{[14
]}

Alawode, Olusegun ^{[15
]}

Omodunbi, Tolulope ^{[16
]}

机构：

[1] Babcock Univ, Benjamin Carson Sch Med, Dept Community Med, Ilishan Remo 000176, Ogun State, Nigeria

[2] APIN Publ Hlth Initiat, Abuja, Nigeria

[3] Ogun State Minist Hlth, Sch Nursing, Ijebu, Nigeria

[4] Babcock Univ, Benjamin Carson Sch Med, Dept Obstet & Gynecol, Ilishan Remo, Ogun State, Nigeria

[5] Babcock Univ, Benjamin Carson Sch Med, Dept Community Med, Ilishan Remo, Ogun State, Nigeria

[6] Nigerian Inst Med Res, Dept Clin Sci, Lagos, Nigeria

[7] Lagos State Univ Teaching Hosp, Dept Pediat, Pediat Infect Dis Unit, Lagos, Nigeria

[8] Ogun State Specialist Hosp, Ota, Ogun State, Nigeria

[9] Fed Med Ctr, Abeokuta, Ogun State, Nigeria

[10] Ogun State Specialist hosp, Ijebu, Ogun State, Nigeria

[11] Ogun State Specialist hosp, Ijaiye, Ogun State, Nigeria

[12] Ogun State Specialist hosp, Ifo, Ogun State, Nigeria

[13] Sacred Heart Hosp, Abeokuta, Ogun State, Nigeria

[14] Adeoyo Matern Teaching Hosp, Ibadan, Oyo State, Nigeria

[15] St Mary Catholic Hosp, Ibadan, Oyo State, Nigeria

[16] OLA Oluyoro Catholic Hosp, Ibadan, Oyo State, Nigeria

来源：

JOURNAL OF ADOLESCENT HEALTH | 2021年 / 68卷 / 04期

关键词：

Acceptability; Adherence; Antiretroviral therapy; Effectiveness; Feasibility; Short message services (SMS); Viral load count; RANDOMIZED CONTROLLED-TRIAL; ANTIRETROVIRAL THERAPY ADHERENCE; SELF-REPORT MEASURES; MEDICATION ADHERENCE; VIRAL LOAD; PEOPLE; YOUTH;

D O I：

10.1016/j.jadohealth.2020.11.016

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Purpose: The study evaluated the feasibility, acceptability, and efficacy of interactive and tailored short message reminders on antiretroviral therapy adherence among adolescents (15-19 years) living with HIV in southwest Nigeria. Methods: The study was a single-blind, parallel-design (ratio 1:1), and multicenter RCT of 209 medication-non-adherent adolescents living with HIV at HIV clinics in two states in southwest Nigeria. The research assessed ART adherence using the visual analog scale, viral suppression, pill count, and ACTG scores; the feasibility of the intervention by the SMS delivery and response (overall and individual) rates; and acceptability using self-report, willingness to continue receiving the intervention, and desire for its scale-up. Results: A total of 17,690 text messages were sent while 10,119 (57.2%) got delivered to the participants. Out of 9,216 responses that were received from the study participants, 8,781 (95.3%) indicated acceptability of the intervention. The end-of-study log(10) of viral load values between control and intervention groups had a mean difference of 0.66 (95% CI 0.26-1.06) and p-value of .001. Also, the unadjusted odds ratio of undetected viral load (<= 20 copies/ml) was 1.356 (1.039-1.771) with a p-value of .002. However, the intervention had no effect on subjective measures of antiretroviral therapy adherence. Conclusions: The use of interactive and tailored short message reminders to enhance antiretroviral therapy adherence among adolescents has good potential. It seems feasible, highly acceptable, and possibly leads to improved viral load count. It is likely that the associated antiretroviral therapy adherence enhances viral suppression and, therefore, improves outcomes in adolescent HIV. (C) 2020 Society for Adolescent Health and Medicine. All rights reserved.

引用

页码：728 / 736

页数：9

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