A Single-Blind, Parallel Design RCT to Assess the Effectiveness of SMS Reminders in Improving ART Adherence Among Adolescents Living with HIV (STARTA Trial)

被引:26
作者
Abiodun, Olumide [1 ]
Ladi-Akinyemi, Babatunde [2 ]
Olu-Abiodun, Oluwatosin [3 ]
Sotunsa, John [4 ]
Bamidele, Fikayo [5 ]
Adepoju, Akinmade [5 ]
David, Nkiru [6 ]
Adekunle, Motunrayo [7 ]
Ogunnubi, Adetutu [8 ]
Imhonopi, Gloria [9 ]
Yinusa, Idayat [10 ]
Erinle, Charles [11 ]
Soetan, Olufemi [12 ]
Arifalo, Gregory [13 ]
Adeyanju, Olusoji [14 ]
Alawode, Olusegun [15 ]
Omodunbi, Tolulope [16 ]
机构
[1] Babcock Univ, Benjamin Carson Sch Med, Dept Community Med, Ilishan Remo 000176, Ogun State, Nigeria
[2] APIN Publ Hlth Initiat, Abuja, Nigeria
[3] Ogun State Minist Hlth, Sch Nursing, Ijebu, Nigeria
[4] Babcock Univ, Benjamin Carson Sch Med, Dept Obstet & Gynecol, Ilishan Remo, Ogun State, Nigeria
[5] Babcock Univ, Benjamin Carson Sch Med, Dept Community Med, Ilishan Remo, Ogun State, Nigeria
[6] Nigerian Inst Med Res, Dept Clin Sci, Lagos, Nigeria
[7] Lagos State Univ Teaching Hosp, Dept Pediat, Pediat Infect Dis Unit, Lagos, Nigeria
[8] Ogun State Specialist Hosp, Ota, Ogun State, Nigeria
[9] Fed Med Ctr, Abeokuta, Ogun State, Nigeria
[10] Ogun State Specialist hosp, Ijebu, Ogun State, Nigeria
[11] Ogun State Specialist hosp, Ijaiye, Ogun State, Nigeria
[12] Ogun State Specialist hosp, Ifo, Ogun State, Nigeria
[13] Sacred Heart Hosp, Abeokuta, Ogun State, Nigeria
[14] Adeoyo Matern Teaching Hosp, Ibadan, Oyo State, Nigeria
[15] St Mary Catholic Hosp, Ibadan, Oyo State, Nigeria
[16] OLA Oluyoro Catholic Hosp, Ibadan, Oyo State, Nigeria
关键词
Acceptability; Adherence; Antiretroviral therapy; Effectiveness; Feasibility; Short message services (SMS); Viral load count; RANDOMIZED CONTROLLED-TRIAL; ANTIRETROVIRAL THERAPY ADHERENCE; SELF-REPORT MEASURES; MEDICATION ADHERENCE; VIRAL LOAD; PEOPLE; YOUTH;
D O I
10.1016/j.jadohealth.2020.11.016
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Purpose: The study evaluated the feasibility, acceptability, and efficacy of interactive and tailored short message reminders on antiretroviral therapy adherence among adolescents (15-19 years) living with HIV in southwest Nigeria. Methods: The study was a single-blind, parallel-design (ratio 1:1), and multicenter RCT of 209 medication-non-adherent adolescents living with HIV at HIV clinics in two states in southwest Nigeria. The research assessed ART adherence using the visual analog scale, viral suppression, pill count, and ACTG scores; the feasibility of the intervention by the SMS delivery and response (overall and individual) rates; and acceptability using self-report, willingness to continue receiving the intervention, and desire for its scale-up. Results: A total of 17,690 text messages were sent while 10,119 (57.2%) got delivered to the participants. Out of 9,216 responses that were received from the study participants, 8,781 (95.3%) indicated acceptability of the intervention. The end-of-study log(10) of viral load values between control and intervention groups had a mean difference of 0.66 (95% CI 0.26-1.06) and p-value of .001. Also, the unadjusted odds ratio of undetected viral load (<= 20 copies/ml) was 1.356 (1.039-1.771) with a p-value of .002. However, the intervention had no effect on subjective measures of antiretroviral therapy adherence. Conclusions: The use of interactive and tailored short message reminders to enhance antiretroviral therapy adherence among adolescents has good potential. It seems feasible, highly acceptable, and possibly leads to improved viral load count. It is likely that the associated antiretroviral therapy adherence enhances viral suppression and, therefore, improves outcomes in adolescent HIV. (C) 2020 Society for Adolescent Health and Medicine. All rights reserved.
引用
收藏
页码:728 / 736
页数:9
相关论文
共 37 条
  • [1] Reproductive health knowledge and services utilization among rural adolescents in east Gojjam zone, Ethiopia: a community-based cross-sectional study
    Abajobir, Amanuel Alemu
    Seme, Assefa
    [J]. BMC HEALTH SERVICES RESEARCH, 2014, 14
  • [2] Abiodun O., 2016, Journal of AIDS and Clinical Research, V7, P576
  • [3] Abiodun O, 2020, SCIINT LAHORE, V32, P515
  • [4] PLHIV are more likely to have mental distress: evidence from a comparison of a cross-section of HIV and diabetes patients at Tertiary Hospitals in Nigeria
    Abiodun, Olumide
    Lawal, Ismail
    Omokanye, Christopher
    [J]. AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 2018, 30 (08): : 1050 - 1057
  • [5] Adherence to combined Antiretroviral therapy (cART) among people living with HIV/AIDS in a Tertiary Hospital in Ilorin, Nigeria
    Anyaike, Chukwuma
    Atoyebi, Oladele Ademola
    Musa, Omotoso Ibrahim
    Bolarinwa, Oladimeji Akeem
    Durowade, Kabir Adekunle
    Ogundiran, Adeniyi
    Babatunde, Oluwole Adeyemi
    [J]. PAN AFRICAN MEDICAL JOURNAL, 2019, 32
  • [6] Interventions to improve adherence to antiretroviral therapy in children with HIV infection
    Bain-Brickley, Deborah
    Butler, Lisa M.
    Kennedy, Gail E.
    Rutherford, George W.
    [J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2011, (12):
  • [7] Prevention of HIV-1 Infection with Early Antiretroviral Therapy
    Cohen, Myron S.
    Chen, Ying Q.
    McCauley, Marybeth
    Gamble, Theresa
    Hosseinipour, Mina C.
    Kumarasamy, Nagalingeswaran
    Hakim, James G.
    Kumwenda, Johnstone
    Grinsztejn, Beatriz
    Pilotto, Jose H. S.
    Godbole, Sheela V.
    Mehendale, Sanjay
    Chariyalertsak, Suwat
    Santos, Breno R.
    Mayer, Kenneth H.
    Hoffman, Irving F.
    Eshleman, Susan H.
    Piwowar-Manning, Estelle
    Wang, Lei
    Makhema, Joseph
    Mills, Lisa A.
    de Bruyn, Guy
    Sanne, Ian
    Eron, Joseph
    Gallant, Joel
    Havlir, Diane
    Swindells, Susan
    Ribaudo, Heather
    Elharrar, Vanessa
    Burns, David
    Taha, Taha E.
    Nielsen-Saines, Karin
    Celentano, David
    Essex, Max
    Fleming, Thomas R.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (06) : 493 - 505
  • [8] Applying a cognitive-behavioral model of HIV risk to youths in psychiatric care
    Donenberg, GR
    Schwartz, RM
    Emerson, E
    Wilson, HW
    Bryant, FB
    Coleman, G
    [J]. AIDS EDUCATION AND PREVENTION, 2005, 17 (03) : 200 - 216
  • [9] Improving Adherence to Antiretroviral Therapy for Youth Living with HIV/AIDS: A Pilot Study Using Personalized, Interactive, Daily Text Message Reminders
    Dowshen, Nadia
    Kuhns, Lisa M.
    Johnson, Amy
    Holoyda, Brian James
    Garofalo, Robert
    [J]. JOURNAL OF MEDICAL INTERNET RESEARCH, 2012, 14 (02)
  • [10] Visual analogue scale (VAS) measurement of antiretroviral adherence in people living with HIV (PLWH): a meta-analysis
    Finitsis, David J.
    Pellowski, Jennifer A.
    Huedo-Medina, Tania B.
    Fox, Matthew C.
    Kalichman, Seth C.
    [J]. JOURNAL OF BEHAVIORAL MEDICINE, 2016, 39 (06) : 1043 - 1055