RETRACTED: MiR-524 inhibits cell proliferation and induces cell apoptosis in thyroid cancer via targeting SPAG9 (Retracted Article)

被引：0
|
作者：
Zhen, Z. [1 ]
Dong, F. [2 ]
Shen, H. [1 ]
Wang, Q. -G. [1 ]
Yang, L. [3 ]
Hu, J. [4 ]
机构：
[1] Peking Univ, Dept Otolaryngol Head & Neck Surg, Hosp 1, Beijing, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Dept Breast & Thyroid Surg, Tongji Med Coll, Wuhan, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Emergency Med, Tongji Med Coll, Wuhan, Hubei, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Otolaryngol Head & Neck Surg, Tongji Med Coll, Wuhan, Hubei, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2018年 / 22卷 / 12期
关键词：
miR-524; Thyroid cancer; Proliferation; Apoptosis; HUMAN PROSTATE-CANCER; GASTRIC-CANCER; HEPATOCELLULAR-CARCINOMA; OVARIAN-CARCINOMA; DOWN-REGULATION; POOR-PROGNOSIS; INVASION; PROMOTES; ANGIOGENESIS; EXPRESSION;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: To investigate the effect of miR-524 on the proliferation of thyroid cancer and its underlying mechanism. PATIENTS AND METHODS: MiR-524 expression levels in thyroid cancer samples and para-cancer tissues were tested by quantitative Real-time polymerase chain reaction (qRT-PCR). Cells proliferative ability and apoptosis were evaluated through methyl thiazolyl tetrazolium (MTT) and apoptosis assays, respectively. Luciferase reporter assay was used to confirm the regulatory mechanism. RESULTS: MiR-524 expression was reduced in thyroid cancer specimen (p<0.05). Up-regulated miR-524 expression inhibited the proliferative ability and enhanced cell apoptosis of thyroid cancer cells. SPAG9 was a target gene of miR-524, and was reversely regulated by miR-524. CONCLUSIONS: MiR-524 represses thyroid cancer cell proliferation and induces cell apoptosis via targeting SPAG9.
引用
收藏
页码：3812 / 3818
页数：7
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