Dose dependence, and therapeutic window for the neuroprotective effects of 17β-estradiol when administered after cerebral ischemia

被引：45
作者：
Liu, Ran [1 ]
Wang, Xiaofei [1 ]
Liu, Qing [1 ]
Yang, Shao-Hua [1 ]
Simpkins, James W. [1 ]
机构：
[1] Univ N Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX 76107 USA
来源：
NEUROSCIENCE LETTERS | 2007年 / 415卷 / 03期
关键词：
estrogen; cerebral-ischemia; neuroprotection;
D O I：
10.1016/j.neulet.2007.01.074
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The present study was undertaken to determine if the neuroprotective effect of 17 beta-estradiol (E-2) when administrated after ischemia is dose-dependent and if the therapeutic window for estrogen can be prolonged. Ischemic injury was induced by permanent middle cerebral artery occlusion (p-MCAO). Administration of E, at 30 min after ischemia resulted in a reduction in lesion volume. A higher dose of E, extended the therapeutic window to 6h after cerebral ischemia in 33% of the rats. These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：237 / 241
页数：5
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