Exosomal Non-coding RNAs-Mediated Crosstalk in the Tumor Microenvironment

被引：46

作者：

Chen, Qi ^{[1
,4
]}

Li, Yuefeng ^{[2
]}

Liu, Yueqin ^{[1
]}

Xu, Wenlin ^{[1
]}

Zhu, Xiaolan ^{[1
,3
,4
]}

机构：

[1] Jiangsu Univ, Affiliated Hosp 4, Dept Oncol & Cent Lab, Zhenjiang, Jiangsu, Peoples R China

[2] Jiangsu Univ, Affiliated People Hosp, Zhenjiang, Jiangsu, Peoples R China

[3] Jiangsu Univ, Affiliated Hosp 4, Reprod Med Ctr, Zhenjiang, Jiangsu, Peoples R China

[4] Jiangsu Univ, Int Genome Ctr, Zhenjiang, Jiangsu, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

基金：

中国国家自然科学基金;

关键词：

exosomes; non-coding RNAs; cancer; stromal cells; biological function;

D O I：

10.3389/fcell.2021.646864

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Exosomes are secreted by different types of cells in tumor microenvironment (TME) and participate in multiple biological processes of tumors. Non-coding RNAs (ncRNAs) enveloped in exosomes and released to the TME are shown to be involved in tumorigenesis and development, as well as act as important intracellular communication mediators. However, the understanding on the exact regulatory functions and substrates of exosomal RNA is still at an early stage. In this review, we provided an overview on recent studies on exosomes mediating the modulation of both tumor cells and immune cells, then summarized the exosomal ncRNAs [such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs)] secreted by tumor cells and stromal cells that exhibited potential capabilities to regulate tumor cell growth, progression, metastasis, drug resistance, and immune response. Our review may hopefully inspire a deeper understanding on the ncRNAs' function as useful biomarkers for the diagnosis, prognosis, and as novel targets therapy for cancer.

引用

页数：18

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