Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis

被引：8

作者：

Xiong, Anji ^{[1
,2
]}

Liu, Qingting ^{[1
]}

Zhong, Jiaxun ^{[1
]}

Cao, Yuzi ^{[1
]}

Xiang, Qilang ^{[1
]}

Hu, Ziyi ^{[1
]}

Zhou, Shifeng ^{[1
]}

Song, Zhuoyao ^{[1
]}

Chen, Huini ^{[1
]}

Zhang, Yan ^{[1
]}

Cui, Hongxu ^{[1
]}

Shuai, Shiquan ^{[1
,2
]}

机构：

[1] North Sichuan Med, Nanchong Cent Hosp, Dept Rheumatol & Immunol, Affiliated Nanchong Cent Hosp, 97 Renmin South Rd, Nanchong, Sichuan, Peoples R China

[2] Inflammat & Immunol Key Lab Nanchong, Nanchong, Sichuan, Peoples R China

来源：

ADVANCES IN RHEUMATOLOGY | 2022年 / 62卷 / 01期

关键词：

Systemic sclerosis; Pulmonary hypertension; Early diagnosis; Mortality; Meta-analysis; ARTERIAL-HYPERTENSION; PROGNOSTIC-FACTORS; SUDDEN-DEATH; SURVIVAL; ECHOCARDIOGRAPHY; SCLERODERMA; PREVALENCE; DIAGNOSIS; CLASSIFICATION; PREDICTORS;

D O I：

10.1186/s42358-022-00239-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Pulmonary hypertension (PH) is a frequent complication of systemic sclerosis (SSc) and is currently one of the primary causes of death in patients with this disease. We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH. Methods We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis. Results The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the meta-analysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval: [2.44, 3.98]). Conclusions This meta-analysis revealed a higher mortality in patients with SSc-associated PH. PH was a significant predictor of death in patients with SSc. Thus, early diagnosis and treatment of PH are important in patients with SSc.

引用

页数：10

共 55 条

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