The transformation of the model organism: a decade of developmental genetics

被引:76
作者
Anderson, KV
Ingham, PW
机构
[1] Mem Sloan Kettering Canc Ctr, Dev Biol Program, New York, NY 10021 USA
[2] Univ Sheffield, Dept Biomed Sci, Ctr Dev Genet, Sheffield S10 2TN, S Yorkshire, England
关键词
D O I
10.1038/ng1105
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The past decade has seen the development of powerful techniques to dissect the molecular processes that regulate development. New tools have been used to reveal the basis of cell polarity, morphogen gradients and regulation of signaling in developing animals. Cell biology and developmental biology have become closely intertwined, and many genes that had been thought of as regulators of general cell biological (housekeeping) functions have been shown to act as specific developmental regulators. Vertebrate developmental genetics is now flourishing, with forward and reverse genetics in both zebrafish and the mouse providing new dimensions to our understanding of development.
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收藏
页码:285 / 293
页数:9
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