Nickel-Catalyzed Asymmetric Propargylic Amination of Propargylic Carbonates Bearing an Internal Alkyne Group

被引：46

作者：

Watanabe, Kouichi ^{[1
]}

Miyazaki, Yusuke ^{[1
]}

Okubo, Masataka ^{[1
]}

Zhou, Biao ^{[1
]}

Tsuji, Hiroaki ^{[1
]}

Kawatsura, Motoi ^{[1
]}

机构：

[1] Nihon Univ, Dept Chem, Coll Humanities & Sci, Setagaya Ku, Tokyo 1568550, Japan

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 17期

基金：

日本学术振兴会;

关键词：

SUBSTITUTION-REACTIONS; ENANTIOSELECTIVE PROPARGYLATION; DIRUTHENIUM COMPLEXES; PHENOL DERIVATIVES; AROMATIC-COMPOUNDS; CROSS-COUPLINGS; DYNEMICIN-A; ALCOHOLS; ESTERS; ALKYLATION;

D O I：

10.1021/acs.orglett.8b02325

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have achieved the nickel-catalyzed asymmetric propargylic amination of propargylic carbonates bearing an internal alkyne group. A wide variety of propargylic carbonates and N-methylaniline derivatives were tolerated under the reaction conditions, providing the corresponding chiral propargylic amines in up to 97% yield with up to 97% ee.

引用

页码：5448 / 5451

页数：4

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