Isolation, Synthesis and Structures of Ginsenoside Derivatives and Their Anti-Tumor Bioactivity

被引：20

作者：

Han, Mei ^{[2
]}

Hou, Jin-Gang ^{[2
]}

Dong, Cheng-Ming ^{[1
]}

Li, Wei ^{[2
,3
]}

Yu, Hao-Lun ^{[2
]}

Zheng, Yi-Nan ^{[2
]}

Chen, Li ^{[3
]}

机构：

[1] Henan Coll Tradit Chinese Med, Dept Pharmaceut Sci, Zhengzhou 450008, Peoples R China

[2] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China

[3] Jilin Univ, Norman Bethune Coll Med, Changchun 130000, Peoples R China

来源：

MOLECULES | 2010年 / 15卷 / 01期

关键词：

isolation; synthesis; ginsenoside-ORh1; PROLIFERATION; ACTIVATION; APOPTOSIS; LEUKEMIA;

D O I：

10.3390/molecules15010399

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protopanaxatriol saponins obtained with AB-8 macroporous resin mainly consisted of ginsenosides Rg(1) and Re. A novel mono-ester of ginsenoside-Rh-1 (ginsenoside-ORh1) was synthesized through further enzymatic hydrolysis and octanoyl chloride modifications. A 53% yield was obtained by a facile synthetic method. The structures were identified on the basis of 1D-NMR and 2D-NMR, as well as ESI-TOF-MS mass spectroscopic analyses. The isolated and synthetic compounds were applied in an anti-tumor bioassay, in which ginsenoside ORh1 showed moderate effects on Murine H22 Hepatoma Cells.

引用

页码：399 / 406

页数：8

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