Synthetic studies on the molybdenum cofactor: Total synthesis of pterindithiolenes by direct dithiolene formation from suitable pterin alkynes

被引：1

作者：

Maity, Annada C. ^{[1
]}

Das, Manas Kumar ^{[1
]}

Maity, Sibaprasad ^{[2
]}

Goswami, Shyamaprosad ^{[1
]}

机构：

[1] Indian Inst Engn Sci & Technol, Dept Chem, Howrah 711103, W Bengal, India

[2] Haldia Inst Technol, Dept Appl Sci, Haldia, W Bengal, India

来源：

SYNTHETIC COMMUNICATIONS | 2018年 / 48卷 / 13期

关键词：

Moco; six and seven membered pterindithiolenes; six membered quinoxaline dithiolenes; UNEQUIVOCAL TOTAL-SYNTHESIS; SULFITE OXIDASE; CONTAINING ENZYMES; MODEL; COMPLEXES; IDENTIFICATION; PTERIDINES; REDUCTASE; RELEVANT; UROTHION;

D O I：

10.1080/00397911.2018.1457697

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, efficient total synthesis of a series of pterindithiolenes (15, 16, 17 and 18) [(5,6-dihydro-[1,4]dithiin or 6,7-dihydro-5H-[1,4]dithiepin systems respectively for six and seven membered dithiolenes] has been reported. The six membered quinoxaline thioketal 9 and seven membered quinoxaline dithiolene 11 have also been synthesized from quinoxaline acetylenic alcohol 5 and the corresponding acetylenic ketone 10 respectively. The synthesis of five membered pterin thioketals 12 and 13 along with the conversion of 13 to the dithiolene 14 by the reaction with NBS is also reported. [GRAPHICS] .

引用

页码：1629 / 1639

页数：11

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