A Rhabdomyoma Within a Multilocular Thymic Cyst in a p53-Null Mouse

被引：1
|
作者：
Starost, M. F. [1 ]
Tsang, K. [2 ]
Zerfas, P. M. [1 ]
Stratakis, C. A. [2 ]
机构：
[1] NIH, Div Vet Resources, Bethesda, MD 20892 USA
[2] NICHHD, Sect Endocrinol & Genet, Program Dev Endocrinol & Genet, NIH, Bethesda, MD 20892 USA
来源：
VETERINARY PATHOLOGY | 2010年 / 47卷 / 01期
基金：
美国国家卫生研究院;
关键词：
genetically engineered mouse; multilocular cyst; myoid cell; p53; gene; thymus; ultrastructure; MYOID CELLS; THYMOMA; HYPERPLASIA; CARCINOMA; TUMOR; CATS; MICE; DOG;
D O I：
10.1177/0300985809353175
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
A 9-month-old p53-null female mouse was found dead in its cage. At necropsy, a large thymic mass encompassed the heart. Microscopically, the mass was composed of numerous varying-sized cysts lined with simple squamous epithelial cells to columnar ciliated cells. Also present within this mass was a large aggregate of loosely arranged fusiform-shaped cells. These cells also were found in smaller numbers in the connective tissue surrounding the cysts. The larger aggregate of fusiform cells was positive for desmin and S-100 and negative for smooth muscle actin. Electron microscopy revealed well-formed Z lines and I bands of skeletal muscle phenotype. A diagnosis of rhabdomyoma within a congenital multilocular thymic cyst was made. The thymus contains a small population of myoid cells, which should be taken in consideration when evaluating thymic tumors.
引用
收藏
页码：132 / 136
页数：5
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