Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones

被引：10

作者：

Sirko, Svetlana M. ^{[1
]}

Gorobets, Nikolay Yu. ^{[1
]}

Musatov, Vladimir I. ^{[1
]}

Desenko, Sergey M. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Dept Chem Heterocycl Cpds, SSI Inst Single Crystals, UA-61001 Kharkov, Ukraine

来源：

MOLECULES | 2009年 / 14卷 / 12期

关键词：

benzimidazole; dihydrobenzo[4,5] imidazo[1,2-a]pyrimidin-4-one library; regioselective alkylation; anti-cancer agents; BENZIMIDAZOLE; INHIBITORS; DESIGN; DERIVATIVES;

D O I：

10.3390/molecules14125223

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo [4,5]imidazo[1,2-a]pyriminin-4-ones for their diversification by regioselective alkylation. Under the conditions established, the alkylation gave 10-alkyl derivatives which permitted the parallel generation of a 500-member library of the title compounds.

引用

页码：5223 / 5234

页数：12

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