Embolization-induced angiogenesis in cerebral arteriovenous malformations

被引：101

作者：

Buell, Thomas J. ^{[1
]}

Ding, Dale ^{[1
]}

Starke, Robert M. ^{[1
]}

Crowley, R. Webster ^{[1
]}

Liu, Kenneth C. ^{[1
]}

机构：

[1] Univ Virginia, Dept Neurosurg, Charlottesville, VA 22908 USA

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2014年 / 21卷 / 11期

关键词：

Angiogenesis; Arteriovenous malformation; Embolization; Hypoxia; Inflammation; Stroke; ENDOTHELIAL GROWTH-FACTOR; SMOOTH-MUSCLE-CELLS; VASCULAR MALFORMATIONS; CLINICAL ARTICLE; STEREOTACTIC RADIOSURGERY; SHEAR-STRESS; ADULT-MOUSE; LONG-TERM; FOLLOW-UP; BRAIN;

D O I：

10.1016/j.jocn.2014.04.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Endovascular occlusion of cerebral arteriovenous malformations (AVM) is often utilized as adjunctive therapy in combination with radiosurgery or microsurgery. Evidence supports that partial occlusion of AVM via endovascular embolization leads to increased angiogenesis. This phenomenon may be a contributing factor to the decreased efficacy of AVM radiosurgery following embolization. We review the literature for potential mechanisms of embolization-induced angiogenesis. A comprehensive literature search was performed using PubMed to identify studies that sought to elucidate the pathophysiology behind embolization-induced angiogenesis. The terms "arteriovenous malformation", "embolization", and "angiogenesis" were used to search for relevant publications individually and together. Three distinct mechanisms for embolization-induced angiogenesis were described in the literature: (1) hypoxia-mediated angiogenesis, (2) inflammatory-mediated angiogenesis, and (3) hemodynamic-mediated angiogenesis. Embolization-induced angiogenesis of cerebral AVM likely results from a combination of the three aforementioned mechanisms. However, future research is necessary to determine the relative contribution of each individual mechanism to overall post-embolization AVM neovascularization. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1866 / 1871

页数：6

共 60 条

[1] Shear stress induces expression of vascular endothelial growth factor receptor Flk-1/KDR through the CT-rich Sp1 binding site [J].

Abumiya, T ;

Sasaguri, T ;

Taba, Y ;

Miwa, Y ;

Miyagi, M .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (06) :907-913

[2] Endovascular Treatment Increases but Gamma Knife Radiosurgery Decreases Angiogenic Activity of Arteriovenous Malformations: An in Vivo Experimental Study Using a Rat Cornea Model [J].

Akakin, Akin ;

Ozkan, Abdulkadir ;

Akgun, Emel ;

Koc, Demet Yalcinkaya ;

Konya, Deniz ;

Pamir, M. Necmettin ;

Kilic, Turker .

NEUROSURGERY, 2010, 66 (01) :121-129

[3] TNF-α induces phenotypic modulation in cerebral vascular smooth muscle cells: implications for cerebral aneurysm pathology [J].

Ali, Muhammad S. ;

Starke, Robert M. ;

Jabbour, Pascal M. ;

Tjoumakaris, Stavropoula I. ;

Gonzalez, L. Fernando ;

Rosenwasser, Robert H. ;

Owens, Gary K. ;

Koch, Walter J. ;

Greig, Nigel H. ;

Dumont, Aaron S. .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2013, 33 (10) :1564-1573

[4] Embolization before radiosurgery reduces the obliteration rate of artericivenous malformations [J].

Andrade-Souza, Yuri M. ;

Ramani, Meera ;

Scora, Daryl ;

Tsao, May N. ;

terBrugge, Karel ;

Schwartz, Michael L. .

NEUROSURGERY, 2007, 60 (03) :443-451

[5] Sprouting from arteriovenous shunt vessels with increased blood flow [J].

Asano, Y ;

Ichioka, S ;

Shibata, M ;

Ando, J ;

Nakatsuka, T .

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 2005, 43 (01) :126-130

[6] Liquid Embolization Material Reduces the Delivered Radiation Dose: Clinical Myth or Reality? [J].

Bing, F. ;

Doucet, R. ;

Lacroix, F. ;

Bahary, J. P. ;

Darsaut, T. ;

Roy, D. ;

Guilbert, F. ;

Raymond, J. ;

Weill, A. .

AMERICAN JOURNAL OF NEURORADIOLOGY, 2012, 33 (02) :320-322

[7] Natural history, evaluation, and management of intracranial vascular malformations [J].

Brown, RD ;

Flemming, KD ;

Meyer, FB ;

Cloft, HJ ;

Pollock, BE ;

Link, ML .

MAYO CLINIC PROCEEDINGS, 2005, 80 (02) :269-281

[8] Interleukin-6 involvement in brain arteriovenous malformations [J].

Chen, YM ;

Pawlikowska, L ;

Yao, JHS ;

Shen, FX ;

Zhai, WW ;

Achrol, AS ;

Lawton, MT ;

Kwok, PY ;

Yang, GY ;

Young, WL .

ANNALS OF NEUROLOGY, 2006, 59 (01) :72-80

[9] Evidence of inflammatory cell involvement in brain arteriovenous malformations [J].

Chen, Yongmei ;

Zhu, Wei ;

Bollen, Andrew W. ;

Lawton, Michael T. ;

Barbaro, Nicholas M. ;

Dowd, Christopher F. ;

Hashimoto, Tomoki ;

Yang, Guo-Yuan ;

Young, William L. .

NEUROSURGERY, 2008, 62 (06) :1340-1349

[10] Soluble Endoglin Modulates Aberrant Cerebral Vascular Remodeling [J].

Chen, Yongmei ;

Hao, Qi ;

Kim, Helen ;

Su, Hua ;

Letarte, Michelle ;

Karumanchi, S. Ananth ;

Lawton, Michael T. ;

Barbaro, Nicholas M. ;

Yang, Guo-Yuan ;

Young, William L. .

ANNALS OF NEUROLOGY, 2009, 66 (01) :19-27

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