The yin and yang of NMDA receptor signalling

被引：520
作者：
Hardingham, GE
Bading, H
机构：
[1] Univ Edinburgh, Royal Sch Vet Studies, Dept Precin Vet Sci, Edinburgh EH9 1QH, Midlothian, Scotland
[2] Interdisciplinary Ctr Neurosci IZN, Dept Neurobiol, D-69120 Heidelberg, Germany
来源：
TRENDS IN NEUROSCIENCES | 2003年 / 26卷 / 02期
关键词：
D O I：
10.1016/S0166-2236(02)00040-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Ca2+ entry through the NMDA subtype of glutamate receptors has the power to determine whether neurons survive or die. Too much NMDA receptor activity is harmful to neurons - but so is too little. Is it a case of too much or too little Ca2+ influx causing cell death or do other factors, such as receptor location or receptor-associated proteins, play a role? Understanding the mechanisms behind this dichotomous signalling is an important area of molecular neuroscience with direct clinical implications.
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页码：81 / 89
页数：9
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