Neuroinflammation and Alzheimer's disease:: critical roles for cytokine/Aβ-induced glial activation, NF-κB, and apolipoprotein E -: Commentary

被引:124
作者
Bales, KR
Du, Y
Holtzman, D
Cordell, B
Paul, SM [1 ]
机构
[1] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA
[2] Indiana Univ, Sch Med, Dept Pharmacol & Toxicol, Indianapolis, IN 46202 USA
[3] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Ctr Study Nervous Syst Injury, St Louis, MO 63110 USA
[5] Scios Inc, Sunnyvale, CA 94086 USA
关键词
D O I
10.1016/S0197-4580(00)00143-3
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
引用
收藏
页码:427 / 432
页数:6
相关论文
共 30 条
[1]  
AKIYAMA H, IN PRESS NEUROBIOL A
[2]  
Bales K. R., 1999, Society for Neuroscience Abstracts, V25, P14
[3]   Apolipoprotein E is essential for amyloid deposition in the APPV717F transgenic mouse model of Alzheimer's disease [J].
Bales, KR ;
Verina, T ;
Cummins, DJ ;
Du, YS ;
Dodel, TC ;
Saura, J ;
Fishman, CE ;
DeLong, CA ;
Piccardo, P ;
Petegnief, V ;
Ghetti, B ;
Paul, SM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :15233-15238
[4]   The NF-κB/Rel family of proteins mediates Aβ-induced neurotoxicity and glial activation [J].
Bales, KR ;
Du, YS ;
Dodel, RC ;
Yan, GM ;
Hamilton-Byrd, E ;
Paul, SM .
MOLECULAR BRAIN RESEARCH, 1998, 57 (01) :63-72
[5]   Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition [J].
Bales, KR ;
Verina, T ;
Dodel, RC ;
Du, YS ;
Altstiel, L ;
Bender, M ;
Hyslop, P ;
Johnstone, EM ;
Little, SP ;
Cummins, DJ ;
Piccardo, P ;
Ghetti, B ;
Paul, SM .
NATURE GENETICS, 1997, 17 (03) :263-264
[6]   Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease [J].
Beffert, U ;
Poirier, J .
NEUROBIOLOGY OF ALZHEIMER'S DISEASE, 1996, 777 :166-174
[7]   APOLIPOPROTEIN-E ASSOCIATED WITH ASTROCYTIC GLIA OF THE CENTRAL NERVOUS-SYSTEM AND WITH NONMYELINATING GLIA OF THE PERIPHERAL NERVOUS-SYSTEM [J].
BOYLES, JK ;
PITAS, RE ;
WILSON, E ;
MAHLEY, RW ;
TAYLOR, JM .
JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (04) :1501-1513
[8]   INFLAMMATORY PROCESSES INDUCE BETA-AMYLOID PRECURSOR PROTEIN-CHANGES IN MOUSE-BRAIN [J].
BRUGG, B ;
DUBREUIL, YL ;
HUBER, G ;
WOLLMAN, EE ;
DELHAYEBOUCHAUD, N ;
MARIANI, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) :3032-3035
[9]   PROTECTIVE EFFECT OF APOLIPOPROTEIN-E TYPE-2 ALLELE FOR LATE-ONSET ALZHEIMER-DISEASE [J].
CORDER, EH ;
SAUNDERS, AM ;
RISCH, NJ ;
STRITTMATTER, WJ ;
SCHMECHEL, DE ;
GASKELL, PC ;
RIMMLER, JB ;
LOCKE, PA ;
CONNEALLY, PM ;
SCHMADER, KE ;
SMALL, GW ;
ROSES, AD ;
HAINES, JL ;
PERICAKVANCE, MA .
NATURE GENETICS, 1994, 7 (02) :180-184
[10]  
DU Y, IN PRESS NEUROLOGY