Biomimetic Nanomedicine Coupled with Neoadjuvant Chemotherapy to Suppress Breast Cancer Metastasis via Tumor Microenvironment Remodeling

被引：46

作者：

Liu, Hai-jun ^{[1
]}

Wang, Junfeng ^{[2
]}

Wang, Mingming ^{[1
]}

Wang, Yuzhen ^{[2
]}

Shi, Shanshan ^{[1
]}

Hu, Xiangxiang ^{[1
]}

Zhang, Quanguang ^{[3
]}

Fan, Daping ^{[2
]}

Xu, Peisheng ^{[1
]}

机构：

[1] Univ South Carolina, Coll Pharm, Dept Discovery & Biomed Sci, 715 Sumter, Columbia, SC 29208 USA

[2] Univ South Carolina, Sch Med, Dept Cell Biol & Anat, 6439 Garners Ferry Rod, Columbia, SC 29209 USA

[3] Augusta Univ, Dept Neurosci & Regenerat Med, Med Coll Georgia, 1120 15th St, Augusta, GA 30912 USA

来源：

ADVANCED FUNCTIONAL MATERIALS | 2021年 / 31卷 / 25期

基金：

美国国家卫生研究院;

关键词：

cancer metastasis; cancer‐ associated fibroblast; cerium oxide nanoparticle; homologous targeting; tumor microenvironment; CERIUM OXIDE NANOPARTICLES; MESENCHYMAL TRANSITION; CELL-MIGRATION; TGF-BETA; FIBROBLASTS; EXPRESSION; PROLIFERATION; MECHANISMS; RESISTANCE; PROTEIN;

D O I：

10.1002/adfm.202100262

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The biomimetic enzyme activity of cerium oxide nanoparticles (CeNPs) prefers ultrasmall particle size and bare surface. Unfortunately, those two features are not favorable for its in vivo application due to easy aggregation and fast renal filtration. To take advantage of the activity of CeNP for cancer therapy, a homologous targeted cerium oxide nanoparticle system, targeted CeNP (T-CeNP), with the integration of a biodegradable dendritic mesoporous silica nanoparticle, superoxide dismutase and catalase mimicking CeNPs, and the camouflage coating of cancer cell membrane has been developed. Attributed to the homologous targeting effect of cancer cell membrane, nanoparticles with camouflage coating are retained in the tumor in an orthotopic breast cancer metastatic model. Subsequently, T-CeNP effectively hinders cancer-associated fibroblast transdifferentiation and reprograms it back to a normal fibroblast. Consequently, T-CeNP coupled with doxorubicin reduces the size of primary tumors and prevents the post-surgery lung metastasis and liver metastasis of breast cancer.

引用

页数：13

共 37 条

[11] Mechanisms of Resistance to Neoadjuvant Chemotherapy in Breast Cancer [J].