Epithelial to mesenchymal transition and breast cancer

被引：233

作者：

Tomaskovic-Crook, Eva ^{[1
]}

Thompson, Erik W. ^{[2
,3
]}

Thiery, Jean Paul ^{[1
]}

机构：

[1] Inst Mol & Cell Biol, Singapore 138673, Singapore

[2] St Vincents Inst Med Res, Melbourne, Vic 3065, Australia

[3] Univ Melbourne, Dept Surg, St Vincents Hosp, Melbourne, Vic 3065, Australia

来源：

BREAST CANCER RESEARCH | 2009年 / 11卷 / 06期

关键词：

CIRCULATING TUMOR-CELLS; BONE-MARROW MICROMETASTASIS; BASAL-LIKE PHENOTYPE; GENE-EXPRESSION; STEM-CELL; MAMMARY-TUMORS; METASTATIC-DISEASE; CLINICAL-RELEVANCE; HISTOLOGICAL GRADE; PROGNOSTIC-FACTOR;

D O I：

10.1186/bcr2416

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epithelial-mesenchymal plasticity in breast carcinoma encompasses the phenotypic spectrum whereby epithelial carcinoma cells within a primary tumor acquire mesenchymal features and re-epithelialize to form a cohesive secondary mass at a metastatic site. Such plasticity has implications in progression of breast carcinoma to metastasis, and will likely influence response to therapy. The transcriptional and epigenetic regulation of molecular and cellular processes that underlie breast cancer and result in characteristic changes in cell behavior can be monitored using an increasing array of marker proteins. Amongst these markers exists the potential for emergent prognostic, predictive and therapeutic targeting.

引用

页数：10

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