Case Report: Changes of Vascular Reactivity and Arterial Stiffness in a Patient With Covid-19 Infection

被引:18
作者
Jud, Philipp [1 ]
Kessler, Harald H. [2 ]
Brodmann, Marianne [1 ]
机构
[1] Med Univ Graz, Div Angiol, Dept Internal Med, Graz, Austria
[2] Med Univ Graz, Diagnost & Res Inst Hyg Microbiol & Environm Med, Graz, Austria
来源
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷
关键词
Covid-19; endothelial dysfunction; vascular reactivity; arterial stiffness; vasculopathy; PREDICTION;
D O I
10.3389/fcvm.2021.671669
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Covid-19 infection may be associated with a higher incidence developing cardiovascular complications, however, the underlying mechanisms contributing to cardiovascular complications are largely unknown, while endothelial cell damage may be present. We want to report a 24-year-old woman with Covid-19 infection who had undergone measurements of vascular reactivity and arterial stiffness, including flow-mediated dilation (FMD), nitroglycerin-mediated dilation (NMD), aortic pulse wave velocity (PWV), augmentation index and carotid intima-media-thickness (cIMT) at the time when Covid-19 was diagnosed. Reduced FMD of 0.0% and NMD of 15.5% were observed, while PWV (5.9 m/s), Aix (27%) and cIMT with 0.4 mm of both common carotid arteries were unremarkable. Repeated measurements of FMD, NMD, PWV, Aix, and cIMT 6 weeks after Covid-19 infection revealed persistently reduced FMD (0.0%), while NMD (17.24%), PWV (5.6 m/s) and augmentation index (13%) ameliorated. This case suggests potential impact of Covid-19 infection on endothelial function, also in young Covid-19 patients without any co-morbidity.
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