Pretreatment with trikatu augments pharmacokinetic profile and bioavailability of orally administered levofloxacin in goat

Pharmacokinetics of levofloxacin in goats, following oral administration (4 mg/kg) was evaluated in trikatu pretreated goats. Reverse-phase High Performance Liquid Chromatography (HPLC) was applied for determination of levofloxacin concentration in plasma concentration. Maximum plasma concentration (C-max), elimination half life (t(1/)(2 beta)), volume of distribution (Vd(area)), total body clearance (Cl-B) and bioavailability were 0.60 +/- 0.03 mu g/ml, 0.95 +/- 0.07 h. 1.91 +/- 0.11 l/kg, 1.06 +/- 0.06 l/h/kg and 21.49 %, respectively observed after oral administration of levofloxacin in goats. In trikatu pretreated goats, pharmacokinetic parameters, viz., maximum plasma concentration (C-max), elimination half-life (t(1/2 beta)), volume of distribution (Vd(area)), total body clearance (Cl-B) and bioavailability were reported as 0.74 +/- 0.03 mu g/ml, 2.07 +/- 0.15 h, 2.98 +/- 0.26 l/kg, 1.02 +/- 0.04 l/h/kg and 30.16 %, respectively. In conclusion. significant difference was observed in majority of pharmacokinetic data of levofloxacin in trikatu pretreated goats than those in normal goats. Trikatu pretreatment in goats significantly increased bioavailability of levofloxacin.