Serotype and VP1 gene sequence of a foot-and-mouth disease virus from Hong Kong (2002)

被引：23

作者：

Feng, Q

Chen, X

Ma, O

Liu, YY

Ding, MX

Collins, RA

Ko, LS

Xing, J

Lau, LT

Yu, ACH

Chen, JG ^{[1
]}

机构：

[1] Peking Univ, Coll Life Sci, Dept Cell Biol & Genet, Beijing 100871, Peoples R China

[2] Hong Kong DNA Chips Ltd, Kowloon, Hong Kong, Peoples R China

[3] Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

[4] Peking Univ, Dept Neurobiol, Beijing 100083, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 302卷 / 04期

关键词：

foot-and-mouth disease; VP1; protein; serotype; Hong Kong;

D O I：

10.1016/S0006-291X(03)00250-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nucleotide sequence of the VP1 coding region of foot-and-mouth disease virus (FMDV) strain HKN/2002, isolated from a disease outbreak occurring in Hong Kong in February 2002, was determined and compared with the sequences of other FMDVs. The VP1 coding region was 639 nucleotides in length and encoded a protein of 213 amino acid residues. Comparison of the VP1 nucleotide sequence with those of other isolates indicated that HKN/2002 belonged to serotype O. A VPI-based sequence similarity tree of several South-east Asian FMDV-0 isolates showed that HKN/2002 was most closely related to FMDV isolates found in Hong Kong from 1991 to 1999 and Taiwan in 1997. Comparison of the amino acid sequence of the major immunogenic region of HKN/2002 with that of the serotype 0 vaccine strain, O1/Manisa/Turkey/69, reveals significant similarity, indicating that current serotype 0 vaccines may offer some degree of protection against HKN/2002. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：715 / 721

页数：7

共 11 条

[1] Delineation of a neutralizing subregion within the immunodominant epitope (GH loop) of foot-and-mouth disease virus VP1 which does not contain the RGD motif [J].